Contents
09 January 2018
Vol 11, Issue 512
Vol 11, Issue 512
Research Articles
- ATM directs DNA damage responses and proteostasis via genetically separable pathways
Independent functions in the response to DNA damage and to oxidative stress broaden the biological roles of the kinase ATM.
- β-Arrestin–biased β-adrenergic signaling promotes extinction learning of cocaine reward memory
Enhancing the activity of the β-arrestin arm of β-adrenergic signaling may help to prevent relapse in cocaine addicts.
- Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation–induced cell death independently of inhibiting glycolysis
Glucose starvation triggers cell death through a calcium-dependent signaling pathway independently of cell energy metabolism.
Editors' Choice
- Antibiotics directly affect host cell metabolism
Antibiotic treatment alters host cell metabolism in a manner that affects both the efficacy of the drug and the immune response to infection.
About The Cover
Online Cover This week features a Research Article that breaks out the kinase ATM from its DNA damage response role and shows independent functions mediating protein homeostasis and the cellular response to oxidative stress. The image shows an artist's depiction of broken DNA. [Image: iStock.com/Firstsignal]