Research ArticleDNA damage ATM directs DNA damage responses and proteostasis via genetically separable pathways View ORCID ProfileJi-Hoon Lee1,*, View ORCID ProfileMichael R. Mand1,*, Chung-Hsuan Kao1, Yi Zhou1, View ORCID ProfileSeung W. Ryu1, Alicia L. Richards2,3, Joshua J. Coon2,3, and View ORCID ProfileTanya T. Paull1,†1Howard Hughes Medical Institute, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.2Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.3Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.↵†Corresponding author. Email: tpaull{at}utexas.edu↵* These authors contributed equally to this work. See allHide authors and affiliations Science Signaling 09 Jan 2018:Vol. 11, Issue 512, eaan5598DOI: 10.1126/scisignal.aan5598 Ji-Hoon Lee 1Howard Hughes Medical Institute, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Ji-Hoon Lee Michael R. Mand 1Howard Hughes Medical Institute, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Michael R. Mand Chung-Hsuan Kao 1Howard Hughes Medical Institute, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Yi Zhou 1Howard Hughes Medical Institute, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Seung W. Ryu 1Howard Hughes Medical Institute, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Seung W. Ryu Alicia L. Richards 2Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.3Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Joshua J. Coon 2Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.3Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Tanya T. Paull 1Howard Hughes Medical Institute, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Tanya T. Paull For correspondence: tpaull@utexas.edu Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 11 no. 512 DOI: https://doi.org/10.1126/scisignal.aan5598 PubMed: 29317520 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received May 1, 2017Accepted November 27, 2017 . Copyright & Usage: Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License. Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: January 2018 to February 2021 AbstractFullPdf Jan 20186060284618 Feb 20184164273 Mar 20182723059 Apr 20182093161 May 20182282828 Jun 20181843038 Jul 20181543039 Aug 20181215937 Sep 2018963916 Oct 20181522818 Nov 20181045114 Dec 2018942512 Jan 20193216538 Feb 2019910938 Mar 20193214152 Apr 201968934 May 201987946 Jun 201948731 Jul 201938926 Aug 201948024 Sep 2019108045 Oct 2019511238 Nov 201966939 Dec 2019311129 Jan 2020111018 Feb 202039841 Mar 2020014655 Apr 2020012896 May 202019068 Jun 2020611481 Jul 202007333 Aug 202027437 Sep 20201310057 Oct 202019846 Nov 202009159 Dec 202066837 Jan 202138942 Feb 202117829 View Full Text
ATM directs DNA damage responses and proteostasis via genetically separable pathways By Ji-Hoon Lee, Michael R. Mand, Chung-Hsuan Kao, Yi Zhou, Seung W. Ryu, Alicia L. Richards, Joshua J. Coon, Tanya T. Paull Science Signaling09 Jan 2018 Independent functions in the response to DNA damage and to oxidative stress broaden the biological roles of the kinase ATM. Supplementary Materials
ATM directs DNA damage responses and proteostasis via genetically separable pathways By Ji-Hoon Lee, Michael R. Mand, Chung-Hsuan Kao, Yi Zhou, Seung W. Ryu, Alicia L. Richards, Joshua J. Coon, Tanya T. Paull Science Signaling09 Jan 2018 Independent functions in the response to DNA damage and to oxidative stress broaden the biological roles of the kinase ATM. Supplementary Materials