Contents
23 January 2018
Vol 11, Issue 514
Vol 11, Issue 514
Research Articles
- Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel
A cavity in the ion channel TRPA1 coordinates electrophilic, voltage, and calcium sensitivity and might be targeted to treat pain and other disorders.
- Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex
Guanabenz attenuates autoimmune inflammation by preventing TLR9 from reaching endosomes and becoming fully activated.
- Biased signaling by thyroid-stimulating hormone receptor–specific antibodies determines thyrocyte survival in autoimmunity
Different autoantibodies against the thyroid-stimulating hormone receptor have distinct effects on receptor trafficking and thyrocyte survival.
Editors' Choice
- Intron splicing for lipid biosynthesis
mTORC1 regulates de novo lipogenesis by enhancing the splicing of introns from transcripts encoding lipogenic enzymes.
About The Cover
Online Cover This week features a Research Article that structurally defines a cavity in the ion channel TRPA1 that critically coordinates the complex manner in which the channel's sensitivity is regulated and in which alterations may underlie chronic pain and other disorders. The image shows a docking model of the channel with phosphoinositides. [Image: Zimova et al., Science Signaling ]