Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex

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  Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex

  By Jessica Perego, Andreia Mendes, Clarisse Bourbon, Voahirana Camosseto, Alexis Combes, Hong Liu, Thien-Phong Vu Manh, Alexandre Dalet, Lionel Chasson, Lionel Spinelli, Nathalie Bardin, Laurent Chiche, Manuel A. S. Santos, Evelina Gatti, Philippe Pierre

  Science Signaling23 Jan 2018

  Guanabenz attenuates autoimmune inflammation by preventing TLR9 from reaching endosomes and becoming fully activated.

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  Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex

  By Jessica Perego, Andreia Mendes, Clarisse Bourbon, Voahirana Camosseto, Alexis Combes, Hong Liu, Thien-Phong Vu Manh, Alexandre Dalet, Lionel Chasson, Lionel Spinelli, Nathalie Bardin, Laurent Chiche, Manuel A. S. Santos, Evelina Gatti, Philippe Pierre

  Science Signaling23 Jan 2018

  Guanabenz attenuates autoimmune inflammation by preventing TLR9 from reaching endosomes and becoming fully activated.

  • Supplementary Materials

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