Research ArticleCancer

KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation

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Science Signaling  30 Jan 2018:
Vol. 11, Issue 515, eaaq1060
DOI: 10.1126/scisignal.aaq1060

The EGFR-cytoskeleton connection

Growth factor signaling stimulates cell proliferation and migration, which requires changes in cell-cell adhesion and the cytoskeleton. Increased activity of the growth factor receptor EGFR is implicated in various cancers. Pike et al. found that EGFR signaling directs changes in cell-cell junctions and the cytoskeleton in lung cancer cells by inducing the phosphorylation of the cell adhesion receptor CAR (see also the Focus by Chiasson-MacKenzie and McClatchey). Phosphorylated CAR interacted with the microtubule motor protein KIF22 to stabilize the peripheral microtubule network, which facilitated cell division and anchorage-independent growth associated with metastasis. It also altered the trafficking of EGFR such that its signaling was prolonged. Thus, CAR or KIF22 might be alternative targets for therapeutically inhibiting EGFR signaling in some cancers.

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