Contents

Research Articles

• Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A

  By Elina Staaf, Per Niklas Hedde, Sunitha Bagawath Singh, Joachim Piguet, Enrico Gratton, Sofia Johansson

  Science Signaling13 Feb 2018 Full AccessRestricted Access

  Dynamic movements of activating and inhibitory receptors distinguish educated natural killer cells from hyporesponsive cells.

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• The unfolded protein response regulator ATF6 promotes mesodermal differentiation

  By Heike Kroeger, Neil Grimsey, Ryan Paxman, Wei-Chieh Chiang, Lars Plate, Ying Jones, Peter X. Shaw, JoAnn Trejo, Stephen H. Tsang, Evan Powers, Jeffery W. Kelly, R. Luke Wiseman, Jonathan H. Lin

  Science Signaling13 Feb 2018 Full AccessRestricted Access

  The proteostasis stress-response protein ATF6 directs the mesodermal lineage during vertebrate embryogenesis and early development.

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• Structural basis for the interaction between the cell polarity proteins Par3 and Par6

  By Fabian A. Renschler, Susanne R. Bruekner, Paulin L. Salomon, Amrita Mukherjee, Lars Kullmann, Mira C. Schütz-Stoffregen, Christine Henzler, Tony Pawson, Michael P. Krahn, Silke Wiesner

  Science Signaling13 Feb 2018 Full AccessRestricted Access

  The association between the polarity proteins Par6 and Par3 requires a motif in Par6 that binds to two of the PDZ domains in Par3.

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