Contents
20 February 2018
Vol 11, Issue 518
Vol 11, Issue 518
Research Articles
- Abl and Arg mediate cysteine cathepsin secretion to facilitate melanoma invasion and metastasis
The kinases Abl and Arg induce the expression and secretion of prometastatic cathepsins in melanoma.
- Coordinating the overall stomatal response of plants: Rapid leaf-to-leaf communication during light stress
Light stress in one part of a plant is communicated to other leaves to coordinate stomatal responses.
- A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin–biased signaling
A disease-associated mutation disrupts a calcium-sensing receptor structural motif and causes biased signaling through β-arrestin.
- The intracellular pyrimidine 5′-nucleotidase NT5C3A is a negative epigenetic factor in interferon and cytokine signaling
An enzyme involved in nucleotide catabolism reduces inflammation through chromatin-mediated suppression of the expression of NF-κB target genes.
Editors' Choice
- Condemned by metabolism
The kinase RIP3 increases aerobic flux to produce reactive oxygen species, which enhances necrosome formation and necroptosis.
About The Cover
Online Cover This week features a Research Article that describes how the kinases Abl and Arg promote melanoma metastasis through the expression of secreted cathepsins. The image shows lesions of cathepsin L–expressing melanoma cells in the lungs of a mouse. [Image: Tripathi et al., Science Signaling]