27 February 2018
Vol 11, Issue 519

About The Cover

Cover image expansion

Online Cover This week features a Research Article that combined RNA microarray, total protein mass spectrometry, and phosphoprotein mass spectrometry analyses of colon samples from a mouse model of colitis to understand the dynamics of disease pathogenesis. Analysis of these trans-omics data sets identified the kinase Pak as a driver of disease. Another Research Article in this issue showed how the protein Daple coordinates multiple signaling pathways that drive colorectal cancer. The image shows a section of noninflamed mouse colon. [Image: Lyons et al./Science Signaling]