Contents
27 February 2018
Vol 11, Issue 519
Vol 11, Issue 519
Research Articles
- Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis
A combination of transcriptomics, proteomics, and phosphoproteomics reveals therapeutic targets in colitis.
- Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple
The protein Daple coordinates cross-talk among growth factor receptors, Wnt, and G protein–coupled signaling pathways to facilitate tumor progression.
- Wdpcp promotes epicardial EMT and epicardium-derived cell migration to facilitate coronary artery remodeling
Coronary artery remodeling during development requires the activity of Wdpcp in the epicardial cell layer.
Editors' Choice
- The cost of being different
Extensive genetic variations in GPCRs may alter responses to commonly used drugs and incur a high economic burden.
- New connections: TGF-β in tumors
Targeting the cytokine TGF-β in the tumor microenvironment enhances antitumor immune responses by infiltrating T cells.
About The Cover
Online Cover This week features a Research Article that combined RNA microarray, total protein mass spectrometry, and phosphoprotein mass spectrometry analyses of colon samples from a mouse model of colitis to understand the dynamics of disease pathogenesis. Analysis of these trans-omics data sets identified the kinase Pak as a driver of disease. Another Research Article in this issue showed how the protein Daple coordinates multiple signaling pathways that drive colorectal cancer. The image shows a section of noninflamed mouse colon. [Image: Lyons et al./Science Signaling]