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Research ArticleInflammation
Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis
- View ORCID ProfileJesse Lyons1,2,*,
- View ORCID ProfileDouglas K. Brubaker1,2,*,
- View ORCID ProfilePhaedra C. Ghazi1,
- View ORCID ProfileKatherine R. Baldwin1,3,
- View ORCID ProfileAmanda Edwards4,5,
- Myriam Boukhali4,5,
- Samantha Dale Strasser1,2,6,
- View ORCID ProfileLucia Suarez-Lopez1,7,
- View ORCID ProfileYi-Jang Lin1,
- View ORCID ProfileVijay Yajnik8,
- Joseph L. Kissil9,
- View ORCID ProfileWilhelm Haas4,5,
- View ORCID ProfileDouglas A. Lauffenburger2,7, and
- View ORCID ProfileKevin M. Haigis1,5,10,†
- 1Cancer Research Institute and Department of Medicine, Beth-Israel Deaconess Medical Center, Boston, MA 02215, USA.
- 2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 3Department of Pediatric Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.
- 4Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA.
- 5Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
- 6Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 7David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 8Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.
- 9Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL 33458, USA.
- 10Harvard Digestive Disease Center, Harvard Medical School, Boston, MA 02115, USA.
- ↵†Corresponding author. Email: khaigis{at}bidmc.harvard.edu
↵* These authors contributed equally to this work.
See allHide authors and affiliations
Science Signaling 27 Feb 2018:
Vol. 11, Issue 519, eaan3580
DOI: 10.1126/scisignal.aan3580
Vol. 11, Issue 519, eaan3580
DOI: 10.1126/scisignal.aan3580
Jesse Lyons
1Cancer Research Institute and Department of Medicine, Beth-Israel Deaconess Medical Center, Boston, MA 02215, USA.
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Douglas K. Brubaker
1Cancer Research Institute and Department of Medicine, Beth-Israel Deaconess Medical Center, Boston, MA 02215, USA.
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Phaedra C. Ghazi
1Cancer Research Institute and Department of Medicine, Beth-Israel Deaconess Medical Center, Boston, MA 02215, USA.
Katherine R. Baldwin
1Cancer Research Institute and Department of Medicine, Beth-Israel Deaconess Medical Center, Boston, MA 02215, USA.
3Department of Pediatric Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.
Amanda Edwards
4Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA.
5Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Myriam Boukhali
4Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA.
5Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Samantha Dale Strasser
1Cancer Research Institute and Department of Medicine, Beth-Israel Deaconess Medical Center, Boston, MA 02215, USA.
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
6Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Lucia Suarez-Lopez
1Cancer Research Institute and Department of Medicine, Beth-Israel Deaconess Medical Center, Boston, MA 02215, USA.
7David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Yi-Jang Lin
1Cancer Research Institute and Department of Medicine, Beth-Israel Deaconess Medical Center, Boston, MA 02215, USA.
Vijay Yajnik
8Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.
Joseph L. Kissil
9Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL 33458, USA.
Wilhelm Haas
4Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA.
5Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Douglas A. Lauffenburger
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Kevin M. Haigis
1Cancer Research Institute and Department of Medicine, Beth-Israel Deaconess Medical Center, Boston, MA 02215, USA.
5Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
10Harvard Digestive Disease Center, Harvard Medical School, Boston, MA 02115, USA.
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