Contents
13 March 2018
Vol 11, Issue 521
Vol 11, Issue 521
Research Articles
- p38α signaling in Langerhans cells promotes the development of IL-17–producing T cells and psoriasiform skin inflammation
Activation of p38α signaling in Langerhans cells, but not in other DC subsets or T cells, controls the development of psoriasis.
- Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors
Resistance to PI3K inhibitors in triple-negative breast cancer is mediated by AKT reactivation by the ubiquitin ligase Skp2.
- Extension of chemotactic pseudopods by nonadherent human neutrophils does not require or cause calcium bursts
Calcium bursts in human neutrophils accompany adhesion-dependent deformations but not extension of purely chemotactic pseudopods.
- TSLP signaling in CD4+ T cells programs a pathogenic T helper 2 cell state
The cytokine TSLP promotes the generation of a pathogenic T cell subset that exacerbates allergic responses.
Editors' Choice
- Epigenetic ignition of melanoma
The histone demethylases LSD1 and JMJD2C enable premalignant melanocytes to escape oncogene-induced senescence and form aggressive melanomas.
About The Cover
Online Cover This week features a Research Article that shows that the cytokine TSLP promotes the generation of pathogenic T cells that exacerbate allergic responses. Given that mice that received T cells lacking the TSLP receptor had reduced allergic responses compared to those of mice receiving wild-type T cells, TSLP may be a good therapeutic target in allergic diseases, such as pediatric asthma. [Image: ElRoi/shutterstock.com]