p38α signaling in Langerhans cells promotes the development of IL-17–producing T cells and psoriasiform skin inflammation

Tingting Zheng; Weiheng Zhao; Hongjin Li; Shuxiu Xiao; Ran Hu; Miaomiao Han; Heng Liu; Yeqiang Liu; Kinya Otsu; Xinguang Liu; Gonghua Huang

doi:10.1126/scisignal.aao1685

Research ArticleImmunology

p38α signaling in Langerhans cells promotes the development of IL-17–producing T cells and psoriasiform skin inflammation

View ORCID ProfileTingting Zheng¹,*,
View ORCID ProfileWeiheng Zhao¹,*,
View ORCID ProfileHongjin Li¹,*,†,
Shuxiu Xiao¹,
Ran Hu¹,
Miaomiao Han²,
Heng Liu³,
Yeqiang Liu⁴,
View ORCID ProfileKinya Otsu⁵,⁶,
Xinguang Liu³, and
View ORCID ProfileGonghua Huang¹,‡

¹Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
²Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
³Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, China.
⁴Shanghai Skin Disease Hospital, Tongji University, Shanghai 200443, China.
⁵Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
⁶Cardiovascular Division, King’s College London, London WC2R 2LS, UK.

↵‡Corresponding author. Email: gonghua.huang{at}shsmu.edu.cn

↵* These authors contributed equally to this work.
↵† Present address: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.

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Science Signaling 13 Mar 2018:
Vol. 11, Issue 521, eaao1685
DOI: 10.1126/scisignal.aao1685

Tingting Zheng

1Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

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ORCID record for Tingting Zheng

Weiheng Zhao

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Hongjin Li

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Shuxiu Xiao

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Ran Hu

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Miaomiao Han

2Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

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Heng Liu

3Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, China.

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Yeqiang Liu

4Shanghai Skin Disease Hospital, Tongji University, Shanghai 200443, China.

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Kinya Otsu

5Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.

6Cardiovascular Division, King’s College London, London WC2R 2LS, UK.

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Xinguang Liu

3Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, China.

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Gonghua Huang

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For correspondence: gonghua.huang@shsmu.edu.cn

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vol. 11 no. 521

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https://doi.org/10.1126/scisignal.aao1685

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Received June 21, 2017
Accepted February 13, 2018
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Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License.

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p38α signaling in Langerhans cells promotes the development of IL-17–producing T cells and psoriasiform skin inflammation

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