Research ArticleImmunology
p38α signaling in Langerhans cells promotes the development of IL-17–producing T cells and psoriasiform skin inflammation
- View ORCID ProfileTingting Zheng1,*,
- View ORCID ProfileWeiheng Zhao1,*,
- View ORCID ProfileHongjin Li1,*,†,
- Shuxiu Xiao1,
- Ran Hu1,
- Miaomiao Han2,
- Heng Liu3,
- Yeqiang Liu4,
- View ORCID ProfileKinya Otsu5,6,
- Xinguang Liu3, and
- View ORCID ProfileGonghua Huang1,‡
- 1Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
- 2Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
- 3Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, China.
- 4Shanghai Skin Disease Hospital, Tongji University, Shanghai 200443, China.
- 5Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
- 6Cardiovascular Division, King’s College London, London WC2R 2LS, UK.
- ↵‡Corresponding author. Email: gonghua.huang{at}shsmu.edu.cn
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Science Signaling 13 Mar 2018:
Vol. 11, Issue 521, eaao1685
DOI: 10.1126/scisignal.aao1685
Vol. 11, Issue 521, eaao1685
DOI: 10.1126/scisignal.aao1685
Tingting Zheng
1Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Weiheng Zhao
1Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Hongjin Li
1Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Shuxiu Xiao
1Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Ran Hu
1Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Miaomiao Han
2Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Heng Liu
3Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, China.
Yeqiang Liu
4Shanghai Skin Disease Hospital, Tongji University, Shanghai 200443, China.
Kinya Otsu
5Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
6Cardiovascular Division, King’s College London, London WC2R 2LS, UK.
Xinguang Liu
3Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, China.
Gonghua Huang
1Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
