The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth

Jianjun Zhang; Jianping Guo; Xing Qin; Bin Wang; Linli Zhang; Yingnan Wang; Wenjian Gan; Pier Paolo Pandolfi; Wantao Chen; Wenyi Wei

doi:10.1126/scisignal.aao1052

Research ArticleCancer

The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth

Jianjun Zhang¹,²,*,
View ORCID ProfileJianping Guo²,*,
Xing Qin¹,*,
Bin Wang²,
Linli Zhang²,
Yingnan Wang¹,
Wenjian Gan²,
Pier Paolo Pandolfi³,
Wantao Chen¹,†, and
View ORCID ProfileWenyi Wei²,†

¹Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of China.
²Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
³Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

↵†Corresponding author. Email: chenwantao196323{at}sjtu.edu.cn (W.C.); wwei2{at}bidmc.harvard.edu (W.W.)

↵* These authors contributed equally to this work.

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Science Signaling 27 Mar 2018:
Vol. 11, Issue 523, eaao1052
DOI: 10.1126/scisignal.aao1052

Jianjun Zhang

1Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of China.

2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Jianping Guo

2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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ORCID record for Jianping Guo

Xing Qin

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Bin Wang

2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Linli Zhang

2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Yingnan Wang

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Wenjian Gan

2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Pier Paolo Pandolfi

3Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Wantao Chen

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For correspondence: chenwantao196323@sjtu.edu.cn wwei2@bidmc.harvard.edu

Wenyi Wei

2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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ORCID record for Wenyi Wei
For correspondence: chenwantao196323@sjtu.edu.cn wwei2@bidmc.harvard.edu

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The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth

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