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Research ArticleCancer
The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth
- Jianjun Zhang1,2,*,
- View ORCID ProfileJianping Guo2,*,
- Xing Qin1,*,
- Bin Wang2,
- Linli Zhang2,
- Yingnan Wang1,
- Wenjian Gan2,
- Pier Paolo Pandolfi3,
- Wantao Chen1,†, and
- View ORCID ProfileWenyi Wei2,†
- 1Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of China.
- 2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
- 3Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
- ↵†Corresponding author. Email: chenwantao196323{at}sjtu.edu.cn (W.C.); wwei2{at}bidmc.harvard.edu (W.W.)
↵* These authors contributed equally to this work.
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Science Signaling 27 Mar 2018:
Vol. 11, Issue 523, eaao1052
DOI: 10.1126/scisignal.aao1052
Vol. 11, Issue 523, eaao1052
DOI: 10.1126/scisignal.aao1052
Jianjun Zhang
1Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of China.
2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Jianping Guo
2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Xing Qin
1Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of China.
Bin Wang
2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Linli Zhang
2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Yingnan Wang
1Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of China.
Wenjian Gan
2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Pier Paolo Pandolfi
3Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Wantao Chen
1Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of China.
Wenyi Wei
2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
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