Contents
03 April 2018
Vol 11, Issue 524
Vol 11, Issue 524
Research Articles
- The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury
Recovery from spinal cord injury is improved by blocking the receptors for Nogo and the opioid peptide nociceptin.
- Mutant and wild-type p53 form complexes with p73 upon phosphorylation by the kinase JNK
Contrary to previous reports, wild-type p53 can interact with p73 to promote cell stress–induced apoptosis.
- Structural basis for the preference of the Arabidopsis thaliana phosphatase RLPH2 for tyrosine-phosphorylated substrates
Structure-function studies show why the plant phosphatase RLPH2 prefers tyrosine-phosphorylated substrates.
- A hierarchy of affinities between cytokine receptors and the common gamma chain leads to pathway cross-talk
Limiting amounts of the common receptor subunit γc result in asymmetric cross-talk among cytokines.
Editors' Choice
- New connections: Cytokines learn to share
Computational modeling provides insights into the consequences for T cells of having a shared receptor subunit for different cytokines.
About The Cover
Online Cover This week features a Research Article that shows that recovery from spinal cord injury is improved by blocking the receptors for the myelin-associated protein Nogo and the opioid peptide nociceptin. The image shows an artist's depiction of a human spinal cord. [Image: iStock.com/alex-mit]
