Contents
10 April 2018
Vol 11, Issue 525
Vol 11, Issue 525
Research Articles
- Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system
Combined experimental and modeling techniques reveal the mechanism of signal relay in the oxygen-sensing FixL-FixJ two-component system.
- mTORC1 controls lysosomal Ca2+ release through the two-pore channel TPC2
The ion channel TPC2 is required for Ca2+ mobilization from lysosomes in response to mTORC1 inhibition and to NAADP.
- The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer
A p38/JNK nuclear translocation–blocking peptide may be therapeutic in various cancers and inflammation-associated diseases.
- A nanoscale reorganization of the IL-15 receptor is triggered by NKG2D in a ligand-dependent manner
The activating receptor NKG2D clusters with the IL-15 receptor in NK cells upon stimulation with ULBP2.
Editors' Choice
- New connections: The complexity of simple signaling systems
Bacterial two-component systems are efficient and versatile but not always simple.
About The Cover
Online Cover This week features a Research Article that explores the structural basis of signaling through a bacterial oxygen-sensing two-component system to stimulate the expression of genes required for nitrogen fixation. The image shows the nodules that contain nitrogen-fixing bacteria on the roots of a soybean plant. [Image: Dan Guravich/Science Source]