mTORC1 controls lysosomal Ca²⁺ release through the two-pore channel TPC2

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  mTORC1 controls lysosomal Ca²⁺ release through the two-pore channel TPC2

  By Oluseye A. Ogunbayo, Jingxian Duan, Jian Xiong, Qiaochu Wang, Xinghua Feng, Jianjie Ma, Michael X. Zhu, A. Mark Evans

  Science Signaling10 Apr 2018

  The ion channel TPC2 is required for Ca²⁺ mobilization from lysosomes in response to mTORC1 inhibition and to NAADP.

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  mTORC1 controls lysosomal Ca²⁺ release through the two-pore channel TPC2

  By Oluseye A. Ogunbayo, Jingxian Duan, Jian Xiong, Qiaochu Wang, Xinghua Feng, Jianjie Ma, Michael X. Zhu, A. Mark Evans

  Science Signaling10 Apr 2018

  The ion channel TPC2 is required for Ca²⁺ mobilization from lysosomes in response to mTORC1 inhibition and to NAADP.

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