mTORC1 controls lysosomal Ca2+ release through the two-pore channel TPC2

Oluseye A. Ogunbayo; Jingxian Duan; Jian Xiong; Qiaochu Wang; Xinghua Feng; Jianjie Ma; Michael X. Zhu; A. Mark Evans

doi:10.1126/scisignal.aao5775

Research ArticleIon Channels

mTORC1 controls lysosomal Ca²⁺ release through the two-pore channel TPC2

Oluseye A. Ogunbayo¹,
Jingxian Duan¹,
Jian Xiong²,
Qiaochu Wang²,
Xinghua Feng²,
Jianjie Ma³,
Michael X. Zhu ², and
A. Mark Evans ¹,*

¹Centres for Discovery Brain Sciences and Cardiovascular Sciences, Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, EH8 9XD Scotland, UK.
²Department of Integrative Biology and Pharmacology, McGovern Medical School, Program in Biochemistry and Cell Biology, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
³Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.

↵*Corresponding author. Email: mark.evans{at}ed.ac.uk

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Science Signaling 10 Apr 2018:
Vol. 11, Issue 525, eaao5775
DOI: 10.1126/scisignal.aao5775

Oluseye A. Ogunbayo

Centres for Discovery Brain Sciences and Cardiovascular Sciences, Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, EH8 9XD Scotland, UK.

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Jingxian Duan

Centres for Discovery Brain Sciences and Cardiovascular Sciences, Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, EH8 9XD Scotland, UK.

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Jian Xiong

Department of Integrative Biology and Pharmacology, McGovern Medical School, Program in Biochemistry and Cell Biology, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

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Qiaochu Wang

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Xinghua Feng

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Jianjie Ma

Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.

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Michael X. Zhu

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A. Mark Evans

Centres for Discovery Brain Sciences and Cardiovascular Sciences, Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, EH8 9XD Scotland, UK.

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For correspondence: mark.evans@ed.ac.uk

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