17 April 2018
Vol 11, Issue 526

About The Cover

Cover image expansion

Online Cover This week features a Research Resource that presents a proteomics analysis of the effects of the cytokine IL-2 on cytotoxic T cells (CTLs), which mediate immune responses against virally infected cells and tumor cells. The analysis reveals how IL-2 shapes the ability of CTLs to sense nutrients and oxygen in their environment, as well as how the cells respond to tofacitinib, a drug used to treat autoimmune and inflammatory conditions. The image is a colored scanning electron micrograph of two T cells attached to a cancer cell. [Image: Steve Gschmeissner/Science Source]