Contents
17 April 2018
Vol 11, Issue 526
Vol 11, Issue 526
Focus
- A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22
The functional activity of the R620W variant of the phosphatase PTPN22 may be determined as much by localization as by catalytic activity.
Research Articles
- Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases
A kinase domain–focused functional genomic screen reveals loss-of-function mutations in a JNK pathway kinase in gastric cancer.
- Estrogen receptor α contributes to T cell–mediated autoimmune inflammation by promoting T cell activation and proliferation
Estrogen receptor α promotes T cell activation and exacerbates autoimmune disease.
Research Resource
- Interleukin-2 shapes the cytotoxic T cell proteome and immune environment–sensing programs
Proteomic analysis reveals how the cytokine IL-2 enables cytotoxic T cells to function and respond to their environment.
Editors' Choice
- Revisiting PD-1 signaling
The protective effect of anti-PD1 therapy in cancer may not require the phosphatase Ptpn11.
About The Cover
Online Cover This week features a Research Resource that presents a proteomics analysis of the effects of the cytokine IL-2 on cytotoxic T cells (CTLs), which mediate immune responses against virally infected cells and tumor cells. The analysis reveals how IL-2 shapes the ability of CTLs to sense nutrients and oxygen in their environment, as well as how the cells respond to tofacitinib, a drug used to treat autoimmune and inflammatory conditions. The image is a colored scanning electron micrograph of two T cells attached to a cancer cell. [Image: Steve Gschmeissner/Science Source]