Research ArticleMetabolism
Jak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis
- Rohollah Babaei1,
- Maximilian Schuster1,
- Irina Meln1,
- Sarah Lerch1,
- Rayane A. Ghandour2,
- Didier F. Pisani2,
- Irem Bayindir-Buchhalter1,*,
- Julia Marx1,
- Shuang Wu1,3,
- Gabriele Schoiswohl4,†,
- Adrian T. Billeter5,
- Damir Krunic6,
- Jan Mauer7,‡,
- Yun-Hee Lee8,
- James G. Granneman9,
- Lars Fischer5,§,
- Beat P. Müller-Stich5,
- Ez-Zoubir Amri2,
- Erin E. Kershaw4,
- Mathias Heikenwälder10,
- Stephan Herzig11,12,¶, and
- Alexandros Vegiopoulos1,¶
- 1DKFZ Junior Group Metabolism and Stem Cell Plasticity (A171), German Cancer Research Center, Heidelberg 69120, Germany.
- 2Université Côte d’Azur, CNRS, Inserm, Institute of Biology Valrose, Nice 06100, France.
- 3Department of Toxicology, School of Public Health, Peking University, Beijing 100191, China.
- 4Division of Endocrinology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
- 5Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg 69120, Germany.
- 6Light Microscopy Facility, German Cancer Research Center, Heidelberg 69120, Germany.
- 7Max Planck Institute for Metabolism Research Cologne, Cologne 50931, Germany.
- 8College of Pharmacy, Yonsei University, Incheon 406-840, South Korea.
- 9Center for Integrative Metabolic and Endocrine Research, Wayne State University School of Medicine, Detroit, MI 48201, USA.
- 10Division of Chronic Inflammation and Cancer (F180), German Cancer Research Center, Heidelberg 69120, Germany.
- 11Helmholtz Center Munich, Institute for Diabetes and Cancer (IDC), Neuherberg 85764, Germany.
- 12Joint Heidelberg–Institute for Diabetes and Cancer Translational Diabetes Program, Heidelberg University Hospital, Heidelberg 69120, Germany.
- ↵¶Corresponding author. Email: a.vegiopoulos{at}dkfz.de (A.V.); stephan.herzig{at}helmholtz-muenchen.de (S.H.)
↵* Present address: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim 69469, Germany.
↵† Present address: Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria.
↵‡ Present address: BioMed X GmbH, Heidelberg 69120, Germany.
↵§ Present address: Klinikum Mittelbaden gGmbH, Baden-Baden 76532, Germany.
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Science Signaling 24 Apr 2018:
Vol. 11, Issue 527, eaai7838
DOI: 10.1126/scisignal.aai7838
Vol. 11, Issue 527, eaai7838
DOI: 10.1126/scisignal.aai7838
Rohollah Babaei
DKFZ Junior Group Metabolism and Stem Cell Plasticity (A171), German Cancer Research Center, Heidelberg 69120, Germany.
Maximilian Schuster
DKFZ Junior Group Metabolism and Stem Cell Plasticity (A171), German Cancer Research Center, Heidelberg 69120, Germany.
Irina Meln
DKFZ Junior Group Metabolism and Stem Cell Plasticity (A171), German Cancer Research Center, Heidelberg 69120, Germany.
Sarah Lerch
DKFZ Junior Group Metabolism and Stem Cell Plasticity (A171), German Cancer Research Center, Heidelberg 69120, Germany.
Rayane A. Ghandour
Université Côte d’Azur, CNRS, Inserm, Institute of Biology Valrose, Nice 06100, France.
Didier F. Pisani
Université Côte d’Azur, CNRS, Inserm, Institute of Biology Valrose, Nice 06100, France.
Irem Bayindir-Buchhalter
DKFZ Junior Group Metabolism and Stem Cell Plasticity (A171), German Cancer Research Center, Heidelberg 69120, Germany.
Julia Marx
DKFZ Junior Group Metabolism and Stem Cell Plasticity (A171), German Cancer Research Center, Heidelberg 69120, Germany.
Shuang Wu
DKFZ Junior Group Metabolism and Stem Cell Plasticity (A171), German Cancer Research Center, Heidelberg 69120, Germany.Department of Toxicology, School of Public Health, Peking University, Beijing 100191, China.
Gabriele Schoiswohl
Division of Endocrinology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Adrian T. Billeter
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg 69120, Germany.
Damir Krunic
Light Microscopy Facility, German Cancer Research Center, Heidelberg 69120, Germany.
Jan Mauer
Max Planck Institute for Metabolism Research Cologne, Cologne 50931, Germany.
Yun-Hee Lee
College of Pharmacy, Yonsei University, Incheon 406-840, South Korea.
James G. Granneman
Center for Integrative Metabolic and Endocrine Research, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Lars Fischer
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg 69120, Germany.
Beat P. Müller-Stich
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg 69120, Germany.
Ez-Zoubir Amri
Université Côte d’Azur, CNRS, Inserm, Institute of Biology Valrose, Nice 06100, France.
Erin E. Kershaw
Division of Endocrinology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Mathias Heikenwälder
Division of Chronic Inflammation and Cancer (F180), German Cancer Research Center, Heidelberg 69120, Germany.
Stephan Herzig
Helmholtz Center Munich, Institute for Diabetes and Cancer (IDC), Neuherberg 85764, Germany.Joint Heidelberg–Institute for Diabetes and Cancer Translational Diabetes Program, Heidelberg University Hospital, Heidelberg 69120, Germany.
Alexandros Vegiopoulos
DKFZ Junior Group Metabolism and Stem Cell Plasticity (A171), German Cancer Research Center, Heidelberg 69120, Germany.