Research ArticleCytoskeleton

Glycerol monolaurate induces filopodia formation by disrupting the association between LAT and SLP-76 microclusters

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Science Signaling  01 May 2018:
Vol. 11, Issue 528, eaam9095
DOI: 10.1126/scisignal.aam9095

Monoglyceride spurs flawed actin rearrangement

Immune cells are sensitive to neutral fats that are often a common ingredient in cosmetics and food preservatives. The monolyceride glycerol monolaurate (GML) inhibits both bacterial growth and T cell receptor (TCR)–induced signaling. Zhang et al. investigated the effect of GML on actin cytoskeletal rearrangements in human T cells by TIRF microscopy and found that GML provoked erroneous filapodial formation after TCR stimulation. Cells treated with GML formed signaling microclusters that lacked an essential adaptor for actin rearrangement and mislocalized Arp2, a critical component of the actin polymerization complex. These data suggest that GML also suppresses T cell responses by preventing appropriate actin cytoskeletal rearrangements.

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