Research ArticleBiochemistry The receptor tyrosine kinase TrkB signals without dimerization at the plasma membrane View ORCID ProfileEitan Erez Zahavi1,*, Noam Steinberg1, View ORCID ProfileTopaz Altman1, Michael Chein1,2, Yuvraj Joshi1,†, Tal Gradus-Pery1, and View ORCID ProfileEran Perlson1,2,‡1Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel.2Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 6997801, Israel.↵‡Corresponding author. Email: eranpe{at}post.tau.ac.il↵* Present address: Division of Cell Biology, Faculty of Science, Utrecht University, Utrecht 3584, Netherlands.↵† Present address: INSERM U1051, Institute for Neurosciences of Montpellier, University of Montpellier, 34091 Montpellier, France. See allHide authors and affiliations Science Signaling 08 May 2018:Vol. 11, Issue 529, eaao4006DOI: 10.1126/scisignal.aao4006 Eitan Erez Zahavi 1Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Eitan Erez Zahavi Noam Steinberg 1Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Topaz Altman 1Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Topaz Altman Michael Chein 1Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel.2Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 6997801, Israel.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Yuvraj Joshi 1Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Tal Gradus-Pery 1Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Eran Perlson 1Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel.2Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 6997801, Israel.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Eran Perlson For correspondence: eranpe@post.tau.ac.il Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 11 no. 529 DOI: https://doi.org/10.1126/scisignal.aao4006 PubMed: 29739881 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received July 16, 2017Accepted April 3, 2018 . Copyright & Usage: Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License. Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: May 2018 to March 2021 AbstractFullPdf May 20184316272379 Jun 20183342146 Jul 20181883647 Aug 20181638629 Sep 20181063916 Oct 20181458228 Nov 2018675917 Dec 20181154411 Jan 2019834211 Feb 2019713312 Mar 20191011911 Apr 2019553716 May 2019207918 Jun 2019012163 Jul 2019210827 Aug 201917628 Sep 201936723 Oct 201917433 Nov 201917417 Dec 2019011229 Jan 2020011450 Feb 202015228 Mar 202009917 Apr 202018327 May 202009745 Jun 202006238 Jul 202015158 Aug 202005515 Sep 202026936 Oct 202007121 Nov 202005626 Dec 202016129 Jan 202135637 Feb 202129438 Mar 2021020 View Full Text
The receptor tyrosine kinase TrkB signals without dimerization at the plasma membrane By Eitan Erez Zahavi, Noam Steinberg, Topaz Altman, Michael Chein, Yuvraj Joshi, Tal Gradus-Pery, Eran Perlson Science Signaling08 May 2018 Contrary to other receptor tyrosine kinases, TrkB does not appear to dimerize at the plasma membrane in response to ligand. Supplementary Materials
The receptor tyrosine kinase TrkB signals without dimerization at the plasma membrane By Eitan Erez Zahavi, Noam Steinberg, Topaz Altman, Michael Chein, Yuvraj Joshi, Tal Gradus-Pery, Eran Perlson Science Signaling08 May 2018 Contrary to other receptor tyrosine kinases, TrkB does not appear to dimerize at the plasma membrane in response to ligand. Supplementary Materials