Contents
15 May 2018
Vol 11, Issue 530
Vol 11, Issue 530
Research Articles
- Global assessment of its network dynamics reveals that the kinase Plk1 inhibits the phosphatase PP6 to promote Aurora A activity
Network analysis shows how the kinase Plk1 supports the mitotic activity of Aurora A.
- Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins
Phosphorylation within conserved motifs in regulatory subunits controls protein phosphatase 1 (PP1) holoenzyme assembly during mitosis.
- A DGKζ-FoxO-ubiquitin proteolytic axis controls fiber size during skeletal muscle remodeling
Increasing DGKζ abundance could enhance skeletal muscle growth or prevent muscle wasting under atrophy-promoting conditions.
- IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs
A high-fat diet causes liver disease by suppressing IRE1α-regulated microRNA biogenesis.
Editors' Choice
- New connections: Kinases and phosphatases in control of mitosis
Two studies in this week’s issue of Science Signaling reveal coordinated regulation of kinases and phosphatases during cell cycle progression.
About The Cover
Online Cover This week features two studies about the coordinated activities of kinases and phosphatases during cell cycle progression. The issue includes a Research Article that reveals new insight on the protein interaction network of the mitotic kinase Plk1 and identifies how Plk1 promotes Aurora A activity during mitosis through inhibitory phosphorylation of the protein phosphatase PP6. The issue also includes a Research Article that demonstrates that mitotic kinases, such as Aurora B, phosphorylate conserved motifs in the regulatory subunits of the protein phosphatase PP1 to prevent assembly of the holoenzyme during mitosis. The image shows fluorescent staining of a cell undergoing mitosis. [Image: Dr. Alexey Khodjakov/Science Source]