15 May 2018
Vol 11, Issue 530

About The Cover

Cover image expansion

Online Cover This week features two studies about the coordinated activities of kinases and phosphatases during cell cycle progression. The issue includes a Research Article that reveals new insight on the protein interaction network of the mitotic kinase Plk1 and identifies how Plk1 promotes Aurora A activity during mitosis through inhibitory phosphorylation of the protein phosphatase PP6. The issue also includes a Research Article that demonstrates that mitotic kinases, such as Aurora B, phosphorylate conserved motifs in the regulatory subunits of the protein phosphatase PP1 to prevent assembly of the holoenzyme during mitosis. The image shows fluorescent staining of a cell undergoing mitosis. [Image: Dr. Alexey Khodjakov/Science Source]