Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks

Mark Grimes; Benjamin Hall; Lauren Foltz; Tyler Levy; Klarisa Rikova; Jeremiah Gaiser; William Cook; Ekaterina Smirnova; Travis Wheeler; Neil R. Clark; Alexander Lachmann; Bin Zhang; Peter Hornbeck; Avi Ma’ayan; Michael Comb

doi:10.1126/scisignal.aaq1087

Research ResourceCancer

Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks

Mark Grimes¹,*,
Benjamin Hall²,
Lauren Foltz¹,
Tyler Levy²,
Klarisa Rikova²,
Jeremiah Gaiser¹,
William Cook¹,
Ekaterina Smirnova¹,
Travis Wheeler¹,
Neil R. Clark³,
Alexander Lachmann³,
Bin Zhang²,
Peter Hornbeck²,
Avi Ma’ayan ³, and
Michael Comb²

¹Division of Biological Sciences, and Department of Computer Science, Department of Mathematical Sciences, University of Montana, Missoula, MT 59812, USA.
²Cell Signaling Technology, Danvers, MA 01923, USA.
³Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, BD2K-LINCS (Big Data to Knowledge Library of Integrated Network-based Cellular Signatures) Data Coordination and Integration Center, Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA.

↵*Corresponding author. Email: mark.grimes{at}mso.umt.edu

See allHide authors and affiliations

Science Signaling 22 May 2018:
Vol. 11, Issue 531, eaaq1087
DOI: 10.1126/scisignal.aaq1087

Mark Grimes

Division of Biological Sciences, and Department of Computer Science, Department of Mathematical Sciences, University of Montana, Missoula, MT 59812, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: mark.grimes@mso.umt.edu

Benjamin Hall

Cell Signaling Technology, Danvers, MA 01923, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Benjamin Hall

Lauren Foltz

Division of Biological Sciences, and Department of Computer Science, Department of Mathematical Sciences, University of Montana, Missoula, MT 59812, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Tyler Levy

Cell Signaling Technology, Danvers, MA 01923, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Klarisa Rikova

Cell Signaling Technology, Danvers, MA 01923, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jeremiah Gaiser

Division of Biological Sciences, and Department of Computer Science, Department of Mathematical Sciences, University of Montana, Missoula, MT 59812, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

William Cook

Division of Biological Sciences, and Department of Computer Science, Department of Mathematical Sciences, University of Montana, Missoula, MT 59812, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ekaterina Smirnova

Division of Biological Sciences, and Department of Computer Science, Department of Mathematical Sciences, University of Montana, Missoula, MT 59812, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ekaterina Smirnova

Travis Wheeler

Division of Biological Sciences, and Department of Computer Science, Department of Mathematical Sciences, University of Montana, Missoula, MT 59812, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Travis Wheeler

Neil R. Clark

Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, BD2K-LINCS (Big Data to Knowledge Library of Integrated Network-based Cellular Signatures) Data Coordination and Integration Center, Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Alexander Lachmann

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Alexander Lachmann

Bin Zhang

Cell Signaling Technology, Danvers, MA 01923, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Peter Hornbeck

Cell Signaling Technology, Danvers, MA 01923, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Peter Hornbeck

Avi Ma’ayan

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Avi Ma’ayan

Michael Comb

Cell Signaling Technology, Danvers, MA 01923, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks

Plain text

Vertical Tabs

Science Signaling

Article Tools