Contents
29 May 2018
Vol 11, Issue 532
Vol 11, Issue 532
Research Articles
- Thrombospondin-1 promotes matrix homeostasis by interacting with collagen and lysyl oxidase precursors and collagen cross-linking sites
Thrombospondin-1 promotes collagen matrix homeostasis through both intracellular and extracellular mechanisms.
- Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium
The metabolic regulator mTORC1 is activated every morning in the retinal pigment epithelium.
- Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange
Phosphorylation of evolutionarily conserved sites enhances the function of the Gα subunit chaperone and regulator Ric-8A.
- R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes
Metabolic reprogramming of germinal center B cells requires the activity of R-Ras2.
Editors' Choice
- Bacterial manipulation of host cell metabolism
A Helicobacter pylori exotoxin manipulates host cell metabolism by inducing amino acid starvation and inhibiting mTORC1 signaling.
About The Cover
Online Cover This week features a Research Article that identifies both intracellular and extracellular functions for thrombospondin-1 (TSP1) in collagen matrix homeostasis. The image shows collagen (red) and TSP1 (green) in human dermal fibroblasts. [Image: Rosini et al., Science Signaling]