R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes

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Science Signaling  29 May 2018:
Vol. 11, Issue 532, eaal1506
DOI: 10.1126/scisignal.aal1506

R-Ras2 revs replication

Germinal centers are specialized lymphoid structures that facilitate the development of high-affinity antibody responses by B cells, a process that requires the guanosine triphosphate hydrolase activity of Ras family members. Mendoza et al. characterized germinal center formation in mice lacking R-Ras2 or other related family members and found that Ras proteins are functionally specialized. Only B cell–intrinsic R-Ras2 activity was necessary for cellular proliferation and germinal center development. R-Ras2 deficiency specifically reduced the expression of mitochondrial tRNAs necessary for mitochondrial replication and glucose metabolism in B cells. These data suggest that R-Ras2 signaling is essential for the metabolic reprograming of germinal center B cells to supply the energy required to generate effective antibody responses.

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