05 June 2018
Vol 11, Issue 533

About The Cover

Cover image expansion

Online Cover This week features two studies about how the cation channel–kinase TRPM7 controls B cell development and function. The issue includes a Research Article that identifies a kinase-independent requirement for TRPM7 in the development of mature peripheral B cells. The issue also includes a Research Article that demonstrates that both the ion channel and kinase activity of TRPM7 are involved in B cell receptor antigen gathering and internalization. The image shows fluorescent staining of a mouse spleen tissue section for B, T, and myeloid cells. [Image: Krishnamoorthy et al./Science Signaling]