Research ArticleION TRANSPORT

The channel-kinase TRPM7 regulates antigen gathering and internalization in B cells

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Science Signaling  05 Jun 2018:
Vol. 11, Issue 533, eaah6692
DOI: 10.1126/scisignal.aah6692

Ion channel activity controls antigen uptake

The TRPM7 magnesium channel is one of only two ion channels that also contain a kinase domain. This dual ion channel–kinase can phosphorylate nonmuscle myosin IIA heavy chain and control cytoskeletal rearrangements. Using TIRF microscopy, Krishnamoorthy et al. found that expression of TRPM7 in B cells controlled actin dynamics and prevented antigen internalization. In activated B cells lacking TRPM7 or TRPM7 kinase activity, more antigen accumulated on the cell surface and activated stronger B cell receptor–dependent signaling. An inhibitor of TRPM7 ion channel activity reduced antigen presentation to T cells. These data identify a previously uncharacterized role for TRPM7 in B cell antigen uptake and presentation.

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