K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair

Pengda Liu; Wenjian Gan; Siyuan Su; Arthur V. Hauenstein; Tian-min Fu; Bradley Brasher; Carsten Schwerdtfeger; Anthony C. Liang; Ming Xu; Wenyi Wei

doi:10.1126/scisignal.aar8133

Research ArticleDNA Repair

K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair

View ORCID ProfilePengda Liu ¹,²,*,†,
Wenjian Gan ¹,*,
Siyuan Su²,*,
Arthur V. Hauenstein³,
View ORCID ProfileTian-min Fu³,
Bradley Brasher⁴,
Carsten Schwerdtfeger⁴,
Anthony C. Liang⁵,
Ming Xu⁶,⁷, and
View ORCID ProfileWenyi Wei ¹,†

¹Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
²Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
³Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115, USA.
⁴Boston Biochem Inc., Cambridge, MA 02139, USA.
⁵Department of Genetics and Howard Hughes Medical Institute, Division of Genetics, Brigham and Women’s Hospital, Harvard University Medical School, Boston, MA 02115, USA.
⁶Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
⁷Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

↵†Corresponding author. Email: pengda_liu{at}med.unc.edu (P.L.); wwei2{at}bidmc.harvard.edu (W.W.)

↵* These authors contributed equally to this work.

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Science Signaling 05 Jun 2018:
Vol. 11, Issue 533, eaar8133
DOI: 10.1126/scisignal.aar8133

Pengda Liu

1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

2Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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ORCID record for Pengda Liu
For correspondence: pengda_liu@med.unc.edu wwei2@bidmc.harvard.edu

Wenjian Gan

1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

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Siyuan Su

2Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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Arthur V. Hauenstein

3Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115, USA.

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Tian-min Fu

3Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115, USA.

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Bradley Brasher

4Boston Biochem Inc., Cambridge, MA 02139, USA.

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Carsten Schwerdtfeger

4Boston Biochem Inc., Cambridge, MA 02139, USA.

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Anthony C. Liang

5Department of Genetics and Howard Hughes Medical Institute, Division of Genetics, Brigham and Women’s Hospital, Harvard University Medical School, Boston, MA 02115, USA.

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Ming Xu

6Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

7Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Wenyi Wei

1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

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ORCID record for Wenyi Wei
For correspondence: pengda_liu@med.unc.edu wwei2@bidmc.harvard.edu

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vol. 11 no. 533

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https://doi.org/10.1126/scisignal.aar8133

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Received December 20, 2017
Accepted May 16, 2018
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Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License.

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K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair

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