Contents
Vol 11, Issue 535
Research Articles
- PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins
Interferon stimulates the ADP-ribosylation–dependent degradation of nonstructural Zika virus proteins necessary for viral replication.
- Oligomerization of MrgC11 and μ-opioid receptors in sensory neurons enhances morphine analgesia
Activating the peripheral sensory receptor MrgC11 may improve opioid use for pain management.
- Inhibition of somatosensory mechanotransduction by annexin A6
The membrane-binding protein annexin A6 suppresses mechanically induced pain in a mouse model of osteoarthritis.
Editors' Choice
- New connections: Engineering DNA repair vulnerability to treat cancer
Drugs that impair DNA repair broaden cancer sensitivity to common therapies.
About The Cover

Online Cover This week features a Research Article that describes a new interferon-stimulated antiviral mechanism important for the control of Zika virus infection. The image shows an artist's depiction of Zika virus. [Image: DNA Illustrations/Science Source]