Contents

Research Articles

• PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins

  By Lili Li, Hui Zhao, Ping Liu, Chunfeng Li, Natalie Quanquin, Xue Ji, Nina Sun, Peishuang Du, Cheng-Feng Qin, Ning Lu, Genhong Cheng

  Sci. Signal.19 Jun 2018 Full AccessRestricted Access

  Interferon stimulates the ADP-ribosylation–dependent degradation of nonstructural Zika virus proteins necessary for viral replication.

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• Oligomerization of MrgC11 and μ-opioid receptors in sensory neurons enhances morphine analgesia

  By Shao-Qiu He, Qian Xu, Vinod Tiwari, Fei Yang, Michael Anderson, Zhiyong Chen, Shaness A. Grenald, Srinivasa N. Raja, Xinzhong Dong, Yun Guan

  Sci. Signal.19 Jun 2018 Full AccessRestricted Access

  Activating the peripheral sensory receptor MrgC11 may improve opioid use for pain management.

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• Inhibition of somatosensory mechanotransduction by annexin A6

  By Ramin Raouf, Stéphane Lolignier, Jane E. Sexton, Queensta Millet, Sonia Santana-Varela, Anna Biller, Alice M. Fuller, Vanessa Pereira, Jyoti S. Choudhary, Mark O. Collins, Stephen E. Moss, Richard Lewis, Julie Tordo, Els Henckaerts, Michael Linden, John N. Wood

  Sci. Signal.19 Jun 2018 Full AccessRestricted Access

  The membrane-binding protein annexin A6 suppresses mechanically induced pain in a mouse model of osteoarthritis.

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