Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

Brijesh K. Singh; Rohit A. Sinha; Madhulika Tripathi; Arturo Mendoza; Kenji Ohba; Jann A. C. Sy; Sherwin Y. Xie; Jin Zhou; Jia Pei Ho; Ching-yi Chang; Yajun Wu; Vincent Giguère; Boon-Huat Bay; Jean-Marc Vanacker; Sujoy Ghosh; Karine Gauthier; Anthony N. Hollenberg; Donald P. McDonnell; Paul M. Yen

doi:10.1126/scisignal.aam5855

Research ArticleMOLECULAR BIOLOGY

Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

Brijesh K. Singh ¹,*,
Rohit A. Sinha¹,²,
Madhulika Tripathi¹,
Arturo Mendoza³,
Kenji Ohba¹,⁴,
Jann A. C. Sy¹,
Sherwin Y. Xie¹,
Jin Zhou¹,
Jia Pei Ho¹,
Ching-yi Chang⁵,
Yajun Wu⁶,
Vincent Giguère⁷,
Boon-Huat Bay⁶,
Jean-Marc Vanacker⁸,
Sujoy Ghosh¹,
Karine Gauthier⁸,
Anthony N. Hollenberg³,
Donald P. McDonnell⁴, and
Paul M. Yen ¹,*

¹Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke–National University of Singapore (NUS) Medical School, Singapore 169857, Singapore.
²Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, Uttar Pradesh, India.
³Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Sciences, 330 Brookline Avenue, Boston, MA 02215, USA.
⁴Department of Internal Medicine, Enshu Hospital, Hamamatsu, Shizuoka 430-0929, Japan.
⁵Department of Pharmacology and Cancer Biology, Duke University School of Medicine, C238A Levine Science Research Center, Durham, NC 27710, USA.
⁶Department of Anatomy, Yong Loo Lin School of Medicine, NUS, Singapore.
⁷Goodman Cancer Research Centre, McGill University, 1160 Pine Avenue West, Montreal, Québec H3A 1A3, Canada.
⁸Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, 46 Allée d’Italie, 69364 Lyon Cedex 07, France.

↵*Corresponding author. Email: paul.yen{at}duke-nus.edu.sg (P.M.Y.); singhbrijeshk{at}duke-nus.edu.sg (B.K.S.)

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Science Signaling 26 Jun 2018:
Vol. 11, Issue 536, eaam5855
DOI: 10.1126/scisignal.aam5855

Brijesh K. Singh

Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke–National University of Singapore (NUS) Medical School, Singapore 169857, Singapore.

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For correspondence: paul.yen@duke-nus.edu.sg singhbrijeshk@duke-nus.edu.sg

Rohit A. Sinha

Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke–National University of Singapore (NUS) Medical School, Singapore 169857, Singapore.Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, Uttar Pradesh, India.

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Madhulika Tripathi

Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke–National University of Singapore (NUS) Medical School, Singapore 169857, Singapore.

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Arturo Mendoza

Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Sciences, 330 Brookline Avenue, Boston, MA 02215, USA.

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Kenji Ohba

Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke–National University of Singapore (NUS) Medical School, Singapore 169857, Singapore.Department of Internal Medicine, Enshu Hospital, Hamamatsu, Shizuoka 430-0929, Japan.

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Jann A. C. Sy

Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke–National University of Singapore (NUS) Medical School, Singapore 169857, Singapore.

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Sherwin Y. Xie

Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke–National University of Singapore (NUS) Medical School, Singapore 169857, Singapore.

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Jin Zhou

Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke–National University of Singapore (NUS) Medical School, Singapore 169857, Singapore.

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Jia Pei Ho

Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke–National University of Singapore (NUS) Medical School, Singapore 169857, Singapore.

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Ching-yi Chang

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, C238A Levine Science Research Center, Durham, NC 27710, USA.

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Yajun Wu

Department of Anatomy, Yong Loo Lin School of Medicine, NUS, Singapore.

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Vincent Giguère

Goodman Cancer Research Centre, McGill University, 1160 Pine Avenue West, Montreal, Québec H3A 1A3, Canada.

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Boon-Huat Bay

Department of Anatomy, Yong Loo Lin School of Medicine, NUS, Singapore.

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Jean-Marc Vanacker

Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, 46 Allée d’Italie, 69364 Lyon Cedex 07, France.

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Sujoy Ghosh

Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke–National University of Singapore (NUS) Medical School, Singapore 169857, Singapore.

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Karine Gauthier

Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, 46 Allée d’Italie, 69364 Lyon Cedex 07, France.

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Anthony N. Hollenberg

Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Sciences, 330 Brookline Avenue, Boston, MA 02215, USA.

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Donald P. McDonnell

Department of Internal Medicine, Enshu Hospital, Hamamatsu, Shizuoka 430-0929, Japan.

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Paul M. Yen

Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke–National University of Singapore (NUS) Medical School, Singapore 169857, Singapore.

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For correspondence: paul.yen@duke-nus.edu.sg singhbrijeshk@duke-nus.edu.sg

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Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

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