Contents
03 July 2018
Vol 11, Issue 537
Vol 11, Issue 537
Focus
- Nuclear import pathway key to rescuing dominant progerin phenotypes
Restoring a nuclear import pathway rescues pathological phenotypes of cells from HGPS patients (Larrieu et al., in 3 July 2018 issue).
Research Articles
- Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway
Inhibition of the acetyltransferase NAT10 rescues a nuclear import pathway in cells from Hutchinson-Gilford progeria syndrome patients.
- Tomosyn functions as a PKCδ-regulated fusion clamp in mast cell degranulation
PKCδ-dependent phosphorylation of the SNARE inhibitor tomosyn reduces mast cell degranulation.
- Evolution of human, chicken, alligator, frog, and zebrafish mineralocorticoid receptors: Allosteric influence on steroid specificity
Analysis of the interactions of multiple steroid ligands with the mineralocorticoid receptor identifies domains involved in activation and inhibition.
Research Resource
- Proteomic analysis of S-nitrosylated nuclear proteins in rat cortical neurons
The S-nitrosylated proteome directs dendritogenesis in developing cortical neurons.
Editors' Choice
- Sunshine for your mind
Moderate exposure to ultraviolet light stimulates glutamate synthesis in the brain and improves learning and memory.
About The Cover
Online Cover This week features a Research Article that describes the complex regulation of the SNARE-inhibitor tomosyn-1 and its role in mast cell degranulation. The pseudocolored transmission electron microscopy image shows a mast cell with the cytoplasm (green) full of very large granules (dark blue), which surround the nucleus (yellow). [Image: Jose Luis Calvo/Shutterstock]