Contents
10 July 2018
Vol 11, Issue 538
Vol 11, Issue 538
Research Articles
- Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity
The kinase ATM stimulates antioxidant metabolism to prevent oxidative stress in cells.
- IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells
AMPK activity is stimulated by IKK-mediated phosphorylation in cancer cells and downstream of inflammatory cytokines.
- The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4+ T cells
VAV1 mediates cross-talk between the CD226 and TCR signaling pathways to enhance production of the proinflammatory cytokine IL-17.
Editors' Choice
- New connections: Putting the brakes on inflammation
By targeting multiple pathways, microRNAs limit inflammation during sepsis.
About The Cover
Online Cover This week features a Research Article that shows how the kinase ATM directs cell metabolism to prevent oxidative stress. The image shows fluorescent staining of mitochondria and the nucleus in NIH 3T3 cells. [Image: Uri Manor, Salk Institute for Biological Studies]