Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity

Yichong Zhang; Ji-Hoon Lee; Tanya T. Paull; Sarah Gehrke; Angelo D’Alessandro; Qianhui Dou; Vadim N. Gladyshev; Elizabeth A. Schroeder; Samantha K. Steyl; Brooke E. Christian; Gerald S. Shadel

doi:10.1126/scisignal.aaq0702

Research ArticleCELL STRESS

Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity

Yichong Zhang¹,
Ji-Hoon Lee²,
Tanya T. Paull²,
Sarah Gehrke³,
Angelo D’Alessandro³,
Qianhui Dou⁴,
Vadim N. Gladyshev⁴,
Elizabeth A. Schroeder ¹,
Samantha K. Steyl⁵,
Brooke E. Christian ⁵,*, and
Gerald S. Shadel ⁶,*

¹Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.
²Howard Hughes Medical Institute, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
³Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO 80045, USA.
⁴Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02155, USA.
⁵Department of Chemistry, Appalachian State University, Boone, NC 28608, USA.
⁶Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

↵*Corresponding author. Email: gshadel{at}salk.edu (G.S.S.); christianbe{at}appstate.edu (B.E.C.)

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Science Signaling 10 Jul 2018:
Vol. 11, Issue 538, eaaq0702
DOI: 10.1126/scisignal.aaq0702

Yichong Zhang

Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.

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Ji-Hoon Lee

Howard Hughes Medical Institute, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.

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Tanya T. Paull

Howard Hughes Medical Institute, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.

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Sarah Gehrke

Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO 80045, USA.

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Angelo D’Alessandro

Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO 80045, USA.

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Qianhui Dou

Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02155, USA.

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Vadim N. Gladyshev

Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02155, USA.

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Elizabeth A. Schroeder

Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.

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Samantha K. Steyl

Department of Chemistry, Appalachian State University, Boone, NC 28608, USA.

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Brooke E. Christian

Department of Chemistry, Appalachian State University, Boone, NC 28608, USA.

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For correspondence: gshadel@salk.edu christianbe@appstate.edu

Gerald S. Shadel

Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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For correspondence: gshadel@salk.edu christianbe@appstate.edu

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