Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity

Yichong Zhang; Ji-Hoon Lee; Tanya T. Paull; Sarah Gehrke; Angelo D’Alessandro; Qianhui Dou; Vadim N. Gladyshev; Elizabeth A. Schroeder; Samantha K. Steyl; Brooke E. Christian; Gerald S. Shadel

doi:10.1126/scisignal.aaq0702

Research ArticleCELL STRESS

Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity

View ORCID ProfileYichong Zhang¹,
View ORCID ProfileJi-Hoon Lee²,
View ORCID ProfileTanya T. Paull²,
View ORCID ProfileSarah Gehrke³,
Angelo D’Alessandro³,
Qianhui Dou⁴,
View ORCID ProfileVadim N. Gladyshev⁴,
Elizabeth A. Schroeder ¹,
View ORCID ProfileSamantha K. Steyl⁵,
View ORCID ProfileBrooke E. Christian ⁵,*, and
View ORCID ProfileGerald S. Shadel ⁶,*

¹Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.
²Howard Hughes Medical Institute, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
³Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO 80045, USA.
⁴Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02155, USA.
⁵Department of Chemistry, Appalachian State University, Boone, NC 28608, USA.
⁶Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

↵*Corresponding author. Email: gshadel{at}salk.edu (G.S.S.); christianbe{at}appstate.edu (B.E.C.)

See allHide authors and affiliations

Science Signaling 10 Jul 2018:
Vol. 11, Issue 538, eaaq0702
DOI: 10.1126/scisignal.aaq0702

Yichong Zhang

1Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Yichong Zhang

Ji-Hoon Lee

2Howard Hughes Medical Institute, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ji-Hoon Lee

Tanya T. Paull

2Howard Hughes Medical Institute, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Tanya T. Paull

Sarah Gehrke

3Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO 80045, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Sarah Gehrke

Angelo D’Alessandro

3Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO 80045, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Qianhui Dou

4Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02155, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Vadim N. Gladyshev

4Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02155, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Vadim N. Gladyshev

Elizabeth A. Schroeder

1Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Samantha K. Steyl

5Department of Chemistry, Appalachian State University, Boone, NC 28608, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Samantha K. Steyl

Brooke E. Christian

5Department of Chemistry, Appalachian State University, Boone, NC 28608, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Brooke E. Christian
For correspondence: gshadel@salk.edu christianbe@appstate.edu

Gerald S. Shadel

6Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Gerald S. Shadel
For correspondence: gshadel@salk.edu christianbe@appstate.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity

Plain text

Vertical Tabs

Science Signaling

Article Tools