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Research ArticleCELL STRESS
Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity
- View ORCID ProfileYichong Zhang1,
- View ORCID ProfileJi-Hoon Lee2,
- View ORCID ProfileTanya T. Paull2,
- View ORCID ProfileSarah Gehrke3,
- Angelo D’Alessandro3,
- Qianhui Dou4,
- View ORCID ProfileVadim N. Gladyshev4,
- Elizabeth A. Schroeder1,
- View ORCID ProfileSamantha K. Steyl5,
- View ORCID ProfileBrooke E. Christian5,*, and
- View ORCID ProfileGerald S. Shadel6,*
- 1Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.
- 2Howard Hughes Medical Institute, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
- 3Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO 80045, USA.
- 4Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02155, USA.
- 5Department of Chemistry, Appalachian State University, Boone, NC 28608, USA.
- 6Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
- ↵*Corresponding author. Email: gshadel{at}salk.edu (G.S.S.); christianbe{at}appstate.edu (B.E.C.)
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Science Signaling 10 Jul 2018:
Vol. 11, Issue 538, eaaq0702
DOI: 10.1126/scisignal.aaq0702
Vol. 11, Issue 538, eaaq0702
DOI: 10.1126/scisignal.aaq0702
Yichong Zhang
1Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.
Ji-Hoon Lee
2Howard Hughes Medical Institute, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Tanya T. Paull
2Howard Hughes Medical Institute, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Sarah Gehrke
3Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO 80045, USA.
Angelo D’Alessandro
3Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO 80045, USA.
Qianhui Dou
4Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02155, USA.
Vadim N. Gladyshev
4Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02155, USA.
Elizabeth A. Schroeder
1Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.
Samantha K. Steyl
5Department of Chemistry, Appalachian State University, Boone, NC 28608, USA.
Brooke E. Christian
5Department of Chemistry, Appalachian State University, Boone, NC 28608, USA.
Gerald S. Shadel
6Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
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