Contents

Research Articles

• Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

  By Chelsea Jenkins, Samuel B. Luty, Julia E. Maxson, Christopher A. Eide, Melissa L. Abel, Corinne Togiai, Eneida R. Nemecek, Daniel Bottomly, Shannon K. McWeeney, Beth Wilmot, Marc Loriaux, Bill H. Chang, Jeffrey W. Tyner

  Science Signaling17 Jul 2018 Full AccessRestricted Access

  Dasatinib or TNK2-specific inhibitors may treat PTPN11-mutant leukemia.

  • Editor's Summary
  • Abstract
  • Full Text
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• Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization

  By Elke Miess, Arisbel B. Gondin, Arsalan Yousuf, Ralph Steinborn, Nadja Mösslein, Yunshi Yang, Martin Göldner, Julia G. Ruland, Moritz Bünemann, Cornelius Krasel, MacDonald J. Christie, Michelle L. Halls, Stefan Schulz, Meritxell Canals

  Science Signaling17 Jul 2018 Full AccessRestricted Access

  High-efficacy opioids enhance receptor desensitization due to rapid and sustained GRK2/β-arrestin interactions.

  • Editor's Summary
  • Abstract
  • Full Text
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• Unique BIR domain sets determine inhibitor of apoptosis protein–driven cell death and NOD2 complex signal specificity

  By Steven M. Chirieleison, Joseph K. Rathkey, Derek W. Abbott

  Science Signaling17 Jul 2018 Full AccessRestricted Access

  The unique positioning of similar domains determines the signaling specificity of IAP family proteins.

  • Editor's Summary
  • Abstract
  • Full Text
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