Contents
14 August 2018
Vol 11, Issue 543
Vol 11, Issue 543
Research Articles
- Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release
Phosphorylation uncouples the functions of the chaperone Hsp72 during mitosis.
- Functional coupling of GABAA/B receptors and the channel TRPV4 mediates rapid progesterone signaling in the oviduct
Progesterone and GABA receptor agonists stimulate cilial beating in the mouse oviduct.
Research Resource
- Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins
A phenotypic screening platform identifies specific inhibitors of individual TLR pathways.
Review
- Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis
Precise spatiotemporal control enables the mitotic kinases Aurora and PLK1 to orchestrate distinct mitotic processes.
Editors' Choice
- Inflammasome SUMOylation
NLRP3 inflammasome activity is inhibited by SUMOylation.
About The Cover
Online Cover This week features a Research Article and a Review that highlight the spatial and temporal control of proteins during mitosis. The image illustrates where the kinases AurA (red), AurB (yellow), and PLK1 (blue) are active during discrete stages of mitosis. [Image: A. Kitterman/Science Signaling]
