Contents
21 August 2018
Vol 11, Issue 544
Vol 11, Issue 544
Research Articles
- Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function
How potently CAR T cells with CD28 or 4-1BB costimulatory domains stimulate intracellular signaling correlates with treatment efficacy.
- Kinase domain dimerization drives RIPK3-dependent necroptosis
Necroptotic cell death is promoted by the dimerization-dependent activation of the kinase RIPK3.
- Stepwise phosphorylation of leukotriene B4 receptor 1 defines cellular responses to leukotriene B4
Sequential phosphorylation of the leukotriene B4 receptor determines specific cellular responses to low and high concentrations of LTB4.
- G protein–coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor
A mutant GPCR exhibits G protein–biased signaling because of defective phosphorylation by GRK, not because of an inability to bind to β-arrestin.
Editors' Choice
- Synthetic lethality with cisplatin
Blocking the kinase MAST1 with lestaurtinib prevents cisplatin resistance in cancers driven by Raf-MEK signaling.
- IL-1 plays backup
Signaling by the cytokine IL-1 provides a backup mechanism to maintain barrier defense during infection by immune-evasive viruses.
About The Cover
Online Cover This week features a Research Article that provides insight into the signaling pathways activated in CAR T cells and suggests how to optimize these therapies. The image shows an illustration of T cells attacking a tumor cell. [Image: Meletios Verras/shutterstock]