28 August 2018
Vol 11, Issue 545

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows that the prosurvival factor Bcl-xL, an effector of the transcriptional regulator RORγt, prevents excessive γc cytokine signaling in developing thymocytes and limits cell metabolism and mitochondrial biogenesis. The image shows an electron micrograph of a double-positive thymocyte from an RORγt-deficient, Bcl-xL transgenic mouse. [Image: Ligons et al./Science Signaling]