Contents
28 August 2018
Vol 11, Issue 545
Vol 11, Issue 545
Research Articles
- RORγt limits the amount of the cytokine receptor γc through the prosurvival factor Bcl-xL in developing thymocytes
The prosurvival factor Bcl-xL prevents excessive γc cytokine signaling in developing T cells.
- Type 2 diabetes–associated variants of the MT2 melatonin receptor affect distinct modes of signaling
Connecting melatonin receptor variants to signaling differences reveals paths to type 2 diabetes therapy.
- TGF-β–mediated enhancement of TH17 cell generation is inhibited by bone morphogenetic protein receptor 1α signaling
BMP receptor 1α activation limits the TGF-β–mediated differentiation of CD4+ T cells that produce the cytokine IL-17.
- Selective inhibition of CaV3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain
Preventing the stabilization of a Ca2+ channel at the surface of sensory neurons attenuates postsurgical pain.
Editors' Choice
- Making cells move with IRE1α
IRE1α promotes cell migration independently of its function as a transducer of ER stress responses.
About The Cover
Online Cover This week features a Research Article that shows that the prosurvival factor Bcl-xL, an effector of the transcriptional regulator RORγt, prevents excessive γc cytokine signaling in developing thymocytes and limits cell metabolism and mitochondrial biogenesis. The image shows an electron micrograph of a double-positive thymocyte from an RORγt-deficient, Bcl-xL transgenic mouse. [Image: Ligons et al./Science Signaling]