Research ArticleT CELLS

TGF-β–mediated enhancement of TH17 cell generation is inhibited by bone morphogenetic protein receptor 1α signaling

See allHide authors and affiliations

Science Signaling  28 Aug 2018:
Vol. 11, Issue 545, eaar2125
DOI: 10.1126/scisignal.aar2125

BMPing up against TGF-β

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor–β (TGF-β) family of cytokines. Within this family, TGF-β is critical to prevent the spontaneous activation of self-reactive T cells and promote the differentiation of T helper 17 (TH17) cells. Browning et al. found that the CD4+ T cell–intrinsic activation of BMP receptor 1α inhibited the differentiation of CD4+ T cells into TH17 cells. Loss of this receptor reprogrammed the transcriptome of effector T cells, promoted exaggerated responses to inflammatory cytokines, and exacerbated disease in a mouse model of colitis. These data suggest that BMPs may antagonize TGF-β to limit effector T cell development and function.

View Full Text

Stay Connected to Science Signaling