Contents
04 September 2018
Vol 11, Issue 546
Vol 11, Issue 546
Focus
- Coping with stress by regulating tRNAs
Codon usage regulates translation in response to stress conditions (Torrent et al., in 4 September 2018 issue).
Research Articles
- Cells alter their tRNA abundance to selectively regulate protein synthesis during stress conditions
Stress-induced changes in tRNA abundance enhance the translation efficiency of stress response proteins.
- Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells
A plant-derived compound may treat patients with diseases caused by Gα mutations.
- The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils
RIPK1-dependent necroptotic cell death stimulates neutrophil NET formation to control MRSA infection.
- Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation
Mutant RAS–selective dependence on the GEF SOS2 reveals tumor cell sensitivity to kinase inhibitors.
Editors' Choice
- Glucocorticoids and PD-1
Signaling by the glucocorticoid receptor in NK cells induces expression of the checkpoint inhibitor PD-1 to prevent immunopathology.
About The Cover
Online Cover This week features a Research Article that demonstrates that neutrophils use necroptotic cell death pathways to stimulate release of DNA- and histone-containing extracellular traps. The pseudocolored scanning electron microscopy image shows neutrophil extracellular traps (tan) capturing spores from the yeast Candida albicans. [Image: Prof. Matthias Gunzer/Science Source]