Contents
11 September 2018
Vol 11, Issue 547
Vol 11, Issue 547
Focus
- Should the clinic matter to nonphysician scientists?
Clinical training for nonphysician scientists may accelerate the pace of translational research.
Research Articles
- Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma
Inhibitors of the kinase CK2 may halt the growth of an aggressive form of medulloblastoma.
- Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production
The plasma membrane lipid PI4P is the main source of phosphoinositides generated by GPCR activation.
- The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors
Transcriptional cofactors YAP and TAZ have distinct roles in promoting proinflammatory cytokine production and tumorigenesis.
Research Resource
- The kinases HipA and HipA7 phosphorylate different substrate pools in Escherichia coli to promote multidrug tolerance
Differences in the targets of HipA and its variant HipA7 may explain why these kinases have different effects on bacterial persistence.
Editors' Choice
- HSV-1 deamidates cGAS
An HSV-1 enzyme represses innate immune responses by deamidating the cytosolic DNA sensor cGAS.
About The Cover
Online Cover This week features a Research Resource that explains why a kinase variant found in uropathogenic strains of Escherichia coli enables these bacteria to better survive exposure to antibiotics. The image shows E. coli colonies growing on an agar plate in a laboratory. [Image: iStock.com/10174593_258]