Contents
18 September 2018
Vol 11, Issue 548
Vol 11, Issue 548
Research Articles
- The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases
The scaffold function of the inositol phosphatase SHIP2 mediates sustained ERK signaling downstream of FGF receptors.
- Single-molecule diffusion-based estimation of ligand effects on G protein–coupled receptors
Single-molecule tracking of GPCR diffusion within the plasma membrane reveals the type of ligand with which it interacts.
- Ca2+ concentration–dependent premature death of igfbp5a−/− fish reveals a critical role of IGF signaling in adaptive epithelial growth
Igfbp5a enables an epithelial cell population in zebrafish to respond to low environmental Ca2+ conditions.
Editors' Choice
- Going nuclear with stress
A mitochondrial-derived peptide regulates nuclear gene expression in response to metabolic stress.
About The Cover
Online Cover This week features a Research Article that uses single-molecule microscopic tracking of GPCRs within the plasma membrane of a cell to determine what kind of ligand is bound to the receptor. With this method, measuring the dynamics of GPCR movement could be used to determine the effect that a candidate drug has without needing to know the intracellular signaling pathways stimulated by that receptor. The image shows the trajectories of individual GPCRs in different colors depending on the dynamics of movement exhibited. [Image: Yanagawa et al./Science Signaling]