18 September 2018
Vol 11, Issue 548

About The Cover

Cover image expansion

Online Cover This week features a Research Article that uses single-molecule microscopic tracking of GPCRs within the plasma membrane of a cell to determine what kind of ligand is bound to the receptor. With this method, measuring the dynamics of GPCR movement could be used to determine the effect that a candidate drug has without needing to know the intracellular signaling pathways stimulated by that receptor. The image shows the trajectories of individual GPCRs in different colors depending on the dynamics of movement exhibited. [Image: Yanagawa et al./Science Signaling]