Research ArticlePhysiology

Ca2+ concentration–dependent premature death of igfbp5a−/− fish reveals a critical role of IGF signaling in adaptive epithelial growth

See allHide authors and affiliations

Science Signaling  18 Sep 2018:
Vol. 11, Issue 548, eaat2231
DOI: 10.1126/scisignal.aat2231

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Stressing out about low Ca2+

Under low Ca2+ conditions, an epithelial cell population in zebrafish known as NaR cells proliferate so that they can take up more Ca2+. Liu et al. found that Igf-binding protein 5A (Igfbp5a) was required for this adaptive proliferation and for survival under low Ca2+ conditions. The defect in NaR adaptive proliferation in igfbp5a−/− zebrafish was rescued by expression of wild-type human or zebrafish IGFBP5 but not two cancer-associated IGFBP5 mutants. Mice deficient in the various IGFBPs lack obvious phenotypes, and these results reveal the importance of using the appropriate physiological conditions to determine the function of IGFBPs.