Research ArticleGPCR SIGNALING
Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9
- Louis M. Luttrell1,2,3,
- Jialu Wang4,
- Bianca Plouffe5,
- Jeffrey S. Smith4,6,
- Lama Yamani7,
- Suneet Kaur4,
- Pierre-Yves Jean-Charles4,
- Christophe Gauthier8,
- Mi-Hye Lee1,
- Biswaranjan Pani4,
- Jihee Kim4,
- Seungkirl Ahn4,
- Sudarshan Rajagopal4,6,
- Eric Reiter8,
- Michel Bouvier5,
- Sudha K. Shenoy4,9,
- Stéphane A. Laporte7,
- Howard A. Rockman4,9,10, and
- Robert J. Lefkowitz4,6,11,*
- 1Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
- 2Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
- 3Research Service of the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29401, USA.
- 4Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
- 5Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec H3C IJ4, Canada.
- 6Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
- 7Department of Medicine, Research Institute of the McGill University Health Center, McGill University, Montreal, Quebec H4A 3J1, Canada.
- 8Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, CNRS, Université de Tours, 37380 Nouzilly, France.
- 9Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
- 10Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
- 11Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.
- ↵*Corresponding author. Email: lefko001{at}receptor-biol.duke.edu
See allHide authors and affiliations
Science Signaling 25 Sep 2018:
Vol. 11, Issue 549, eaat7650
DOI: 10.1126/scisignal.aat7650
Vol. 11, Issue 549, eaat7650
DOI: 10.1126/scisignal.aat7650
Louis M. Luttrell
Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.Research Service of the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29401, USA.
Jialu Wang
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Bianca Plouffe
Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec H3C IJ4, Canada.
Jeffrey S. Smith
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
Lama Yamani
Department of Medicine, Research Institute of the McGill University Health Center, McGill University, Montreal, Quebec H4A 3J1, Canada.
Suneet Kaur
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Pierre-Yves Jean-Charles
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Christophe Gauthier
Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, CNRS, Université de Tours, 37380 Nouzilly, France.
Mi-Hye Lee
Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Biswaranjan Pani
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Jihee Kim
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Seungkirl Ahn
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Sudarshan Rajagopal
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
Eric Reiter
Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, CNRS, Université de Tours, 37380 Nouzilly, France.
Michel Bouvier
Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec H3C IJ4, Canada.
Sudha K. Shenoy
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
Stéphane A. Laporte
Department of Medicine, Research Institute of the McGill University Health Center, McGill University, Montreal, Quebec H4A 3J1, Canada.
Howard A. Rockman
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Robert J. Lefkowitz
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.
