Research ArticleGPCR SIGNALING
Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9
- View ORCID ProfileLouis M. Luttrell1,2,3,
- Jialu Wang4,
- View ORCID ProfileBianca Plouffe5,
- View ORCID ProfileJeffrey S. Smith4,6,
- Lama Yamani7,
- Suneet Kaur4,
- Pierre-Yves Jean-Charles4,
- Christophe Gauthier8,
- Mi-Hye Lee1,
- View ORCID ProfileBiswaranjan Pani4,
- Jihee Kim4,
- Seungkirl Ahn4,
- View ORCID ProfileSudarshan Rajagopal4,6,
- Eric Reiter8,
- View ORCID ProfileMichel Bouvier5,
- View ORCID ProfileSudha K. Shenoy4,9,
- View ORCID ProfileStéphane A. Laporte7,
- Howard A. Rockman4,9,10, and
- View ORCID ProfileRobert J. Lefkowitz4,6,11,*
- 1Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
- 2Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
- 3Research Service of the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29401, USA.
- 4Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
- 5Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec H3C IJ4, Canada.
- 6Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
- 7Department of Medicine, Research Institute of the McGill University Health Center, McGill University, Montreal, Quebec H4A 3J1, Canada.
- 8Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, CNRS, Université de Tours, 37380 Nouzilly, France.
- 9Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
- 10Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
- 11Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.
- ↵*Corresponding author. Email: lefko001{at}receptor-biol.duke.edu
See allHide authors and affiliations
Science Signaling 25 Sep 2018:
Vol. 11, Issue 549, eaat7650
DOI: 10.1126/scisignal.aat7650
Vol. 11, Issue 549, eaat7650
DOI: 10.1126/scisignal.aat7650
Louis M. Luttrell
1Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
2Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
3Research Service of the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29401, USA.
Jialu Wang
4Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Bianca Plouffe
5Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec H3C IJ4, Canada.
Jeffrey S. Smith
4Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
6Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
Lama Yamani
7Department of Medicine, Research Institute of the McGill University Health Center, McGill University, Montreal, Quebec H4A 3J1, Canada.
Suneet Kaur
4Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Pierre-Yves Jean-Charles
4Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Christophe Gauthier
8Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, CNRS, Université de Tours, 37380 Nouzilly, France.
Mi-Hye Lee
1Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Biswaranjan Pani
4Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Jihee Kim
4Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Seungkirl Ahn
4Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Sudarshan Rajagopal
4Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
6Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
Eric Reiter
8Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, CNRS, Université de Tours, 37380 Nouzilly, France.
Michel Bouvier
5Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec H3C IJ4, Canada.
Sudha K. Shenoy
4Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
9Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
Stéphane A. Laporte
7Department of Medicine, Research Institute of the McGill University Health Center, McGill University, Montreal, Quebec H4A 3J1, Canada.
Howard A. Rockman
4Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
9Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
10Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Robert J. Lefkowitz
4Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
6Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
11Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.
