Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1

Sam A. Jamieson; Zheng Ruan; Abigail E. Burgess; Jack R. Curry; Hamish D. McMillan; Jodi L. Brewster; Anita K. Dunbier; Alison D. Axtman; Natarajan Kannan; Peter D. Mace

doi:10.1126/scisignal.aau0597

Research ArticleBiochemistry

Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1

View ORCID ProfileSam A. Jamieson¹,*,
View ORCID ProfileZheng Ruan²,*,
View ORCID ProfileAbigail E. Burgess¹,
View ORCID ProfileJack R. Curry¹,
View ORCID ProfileHamish D. McMillan¹,
View ORCID ProfileJodi L. Brewster¹,
View ORCID ProfileAnita K. Dunbier¹,
View ORCID ProfileAlison D. Axtman³,⁴,
Natarajan Kannan ²,⁵, and
View ORCID ProfilePeter D. Mace ¹,†

¹Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.
²Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.
³Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
⁴Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
⁵Department of Biochemistry & Molecular Biology, University of Georgia, Athens, GA 30602, USA.

↵†Corresponding author. Email: peter.mace{at}otago.ac.nz

↵* These authors contributed equally to this work.

See allHide authors and affiliations

Science Signaling 25 Sep 2018:
Vol. 11, Issue 549, eaau0597
DOI: 10.1126/scisignal.aau0597

Sam A. Jamieson

1Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Sam A. Jamieson

Zheng Ruan

2Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Zheng Ruan

Abigail E. Burgess

1Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Abigail E. Burgess

Jack R. Curry

1Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jack R. Curry

Hamish D. McMillan

1Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Hamish D. McMillan

Jodi L. Brewster

1Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jodi L. Brewster

Anita K. Dunbier

1Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Anita K. Dunbier

Alison D. Axtman

3Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

4Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Alison D. Axtman

Natarajan Kannan

2Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.

5Department of Biochemistry & Molecular Biology, University of Georgia, Athens, GA 30602, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Peter D. Mace

1Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Peter D. Mace
For correspondence: peter.mace@otago.ac.nz

Article
Figures & Data
Info & Metrics
eLetters
PDF

Article Information

vol. 11 no. 549

DOI:

https://doi.org/10.1126/scisignal.aau0597

PubMed:

Published By:

Print ISSN:

Online ISSN:

History:

Received May 2, 2018
Accepted September 6, 2018
.

Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License.

Author Information

Altmetric

Article usage

Article usage: September 2018 to May 2020

	Abstract	Full	Pdf
Sep 2018	0	3848	680
Oct 2018	256	1357	261
Nov 2018	145	79	45
Dec 2018	98	29	15
Jan 2019	121	57	33
Feb 2019	86	29	22
Mar 2019	93	41	32
Apr 2019	58	47	15
May 2019	62	34	18
Jun 2019	77	34	16
Jul 2019	80	24	14
Aug 2019	34	60	22
Sep 2019	59	19	23
Oct 2019	6	87	47
Nov 2019	3	70	24
Dec 2019	3	85	22
Jan 2020	2	94	41
Feb 2020	7	74	47
Mar 2020	4	65	36
Apr 2020	1	54	19
May 2020	5	31	19

View Full Text

Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1

Article Information

Author Information

Altmetric

Article usage

Article usage: September 2018 to May 2020

Science Signaling

Article Tools