Research ArticleBiochemistry
Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1
- Sam A. Jamieson1,*,
- Zheng Ruan2,*,
- Abigail E. Burgess1,
- Jack R. Curry1,
- Hamish D. McMillan1,
- Jodi L. Brewster1,
- Anita K. Dunbier1,
- Alison D. Axtman3,4,
- Natarajan Kannan2,5, and
- Peter D. Mace1,†
- 1Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.
- 2Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.
- 3Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- 4Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- 5Department of Biochemistry & Molecular Biology, University of Georgia, Athens, GA 30602, USA.
- ↵†Corresponding author. Email: peter.mace{at}otago.ac.nz
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Sci. Signal. 25 Sep 2018:
Vol. 11, Issue 549, eaau0597
DOI: 10.1126/scisignal.aau0597
