Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1

Sam A. Jamieson; Zheng Ruan; Abigail E. Burgess; Jack R. Curry; Hamish D. McMillan; Jodi L. Brewster; Anita K. Dunbier; Alison D. Axtman; Natarajan Kannan; Peter D. Mace

doi:10.1126/scisignal.aau0597

Research ArticleBiochemistry

Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1

View ORCID ProfileSam A. Jamieson¹,*,
View ORCID ProfileZheng Ruan²,*,
View ORCID ProfileAbigail E. Burgess¹,
View ORCID ProfileJack R. Curry¹,
View ORCID ProfileHamish D. McMillan¹,
View ORCID ProfileJodi L. Brewster¹,
View ORCID ProfileAnita K. Dunbier¹,
View ORCID ProfileAlison D. Axtman³,⁴,
Natarajan Kannan ²,⁵, and
View ORCID ProfilePeter D. Mace ¹,†

¹Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.
²Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.
³Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
⁴Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
⁵Department of Biochemistry & Molecular Biology, University of Georgia, Athens, GA 30602, USA.

↵†Corresponding author. Email: peter.mace{at}otago.ac.nz

↵* These authors contributed equally to this work.

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Science Signaling 25 Sep 2018:
Vol. 11, Issue 549, eaau0597
DOI: 10.1126/scisignal.aau0597

Sam A. Jamieson

1Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.

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Zheng Ruan

2Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.

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Abigail E. Burgess

1Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.

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ORCID record for Abigail E. Burgess

Jack R. Curry

1Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.

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ORCID record for Jack R. Curry

Hamish D. McMillan

1Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.

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Jodi L. Brewster

1Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.

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Anita K. Dunbier

1Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.

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Alison D. Axtman

3Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

4Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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Natarajan Kannan

2Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.

5Department of Biochemistry & Molecular Biology, University of Georgia, Athens, GA 30602, USA.

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Peter D. Mace

1Biochemistry Department, School of Biomedical Sciences, University of Otago, P.O. Box 56, 710 Cumberland Street, Dunedin 9054, New Zealand.

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For correspondence: peter.mace@otago.ac.nz

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vol. 11 no. 549

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https://doi.org/10.1126/scisignal.aau0597

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Received May 2, 2018
Accepted September 6, 2018
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Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License.

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Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1

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