Contents
02 October 2018
Vol 11, Issue 550
Vol 11, Issue 550
Research Articles
- The LKB1–AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria
Perfusion-ventilation matching in the lungs requires AMPK-α1 and AMPK-α2 activation downstream of LKB1.
- The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury
A receptor tyrosine kinase may coordinate responses to hypoxia-associated losses in extracellular matrix integrity.
- The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling
A bacterial toxin effector domain disrupts RAS-ERK signaling by cleaving RAS through an unusual mechanism.
- Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses
Autocrine responses to interleukin-6 family cytokines are insensitive to extracellular gp130 signaling receptor blockade.
Editors' Choice
- New connections: Kinase inhibitors as antivirals
Proteomics approaches identify diverse host kinases as potential antiviral therapeutic targets.
About The Cover
Online Cover This week features a Research Article that describes how the kinase AMPK causes pulmonary arteries to constrict in response to hypoxia to ensure that blood is diverted to oxygen-rich areas in the lung. This process, which is called hypoxic pulmonary vasoconstriction, is normally transient but is prolonged under certain circumstances, such as during ascent to altitude. The image shows a mountain climber at high altitude. [Image: iStock.com/rcaucino]