Research ArticleCytokines

Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses

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Science Signaling  02 Oct 2018:
Vol. 11, Issue 550, eaar7388
DOI: 10.1126/scisignal.aar7388

Inside IL-6 inflammation

Members of the interleukin-6 (IL-6) family of proinflammatory cytokines, which includes IL-6 and IL-11, stimulate responses by binding to a complex of their cytokine-specific receptor and the gp130 signaling receptor. Both of these receptor subunits can be shed from the cell surface and regulate distinct mechanisms of gp130-mediated signaling. Lamertz et al. engineered a reductionist system to interrogate how cells respond to wild-type and synthetic IL-6 and IL-11 cytokines. The authors found that a soluble form of gp130 blocked responses to IL-6 and IL-11 that were presented in trans by a neighboring cell. In contrast, extracellular blockade of cell surface gp130 had no effect on the response to autocrine IL-6, suggesting that these responses could occur within the cell.

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