Research ArticleCytokines Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses View ORCID ProfileLarissa Lamertz1, Franziska Rummel1, View ORCID ProfileRobin Polz1, Paul Baran1, Selina Hansen1, Georg H. Waetzig2, Jens M. Moll1, View ORCID ProfileDoreen M. Floss1, and Jürgen Scheller1,*1Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf 40225, Germany.2CONARIS Research Institute AG, Kiel 24118, Germany.↵*Corresponding author. Email: jscheller{at}uni-duesseldorf.de See allHide authors and affiliations Science Signaling 02 Oct 2018:Vol. 11, Issue 550, eaar7388DOI: 10.1126/scisignal.aar7388 Larissa Lamertz 1Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf 40225, Germany.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Larissa Lamertz Franziska Rummel 1Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf 40225, Germany.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Robin Polz 1Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf 40225, Germany.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Robin Polz Paul Baran 1Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf 40225, Germany.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Selina Hansen 1Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf 40225, Germany.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Georg H. Waetzig 2CONARIS Research Institute AG, Kiel 24118, Germany.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Jens M. Moll 1Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf 40225, Germany.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Doreen M. Floss 1Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf 40225, Germany.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Doreen M. Floss Jürgen Scheller 1Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf 40225, Germany.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: jscheller@uni-duesseldorf.de Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 11 no. 550 DOI: https://doi.org/10.1126/scisignal.aar7388 PubMed: 30279168 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received December 12, 2017Accepted September 13, 2018 . Copyright & Usage: Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License. Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: October 2018 to April 2021 AbstractFullPdf Oct 20183253331165 Nov 20181053723 Dec 20182102817 Jan 20192172313 Feb 20191472918 Mar 2019712312 Apr 2019571815 May 2019683420 Jun 2019671812 Jul 2019541912 Aug 201952328 Sep 2019352314 Oct 201947728 Nov 201947126 Dec 201928819 Jan 202009454 Feb 202026940 Mar 202008847 Apr 2020011051 May 2020015767 Jun 2020211155 Jul 2020012237 Aug 2020011746 Sep 2020311257 Oct 2020012763 Nov 202008948 Dec 2020212854 Jan 202128652 Feb 202108645 Mar 2021010257 Apr 202103811 View Full Text
Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses By Larissa Lamertz, Franziska Rummel, Robin Polz, Paul Baran, Selina Hansen, Georg H. Waetzig, Jens M. Moll, Doreen M. Floss, Jürgen Scheller Science Signaling02 Oct 2018 Autocrine responses to interleukin-6 family cytokines are insensitive to extracellular gp130 signaling receptor blockade. Supplementary Materials
Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses By Larissa Lamertz, Franziska Rummel, Robin Polz, Paul Baran, Selina Hansen, Georg H. Waetzig, Jens M. Moll, Doreen M. Floss, Jürgen Scheller Science Signaling02 Oct 2018 Autocrine responses to interleukin-6 family cytokines are insensitive to extracellular gp130 signaling receptor blockade. Supplementary Materials