Research ArticleStress responses

The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury

See allHide authors and affiliations

Science Signaling  02 Oct 2018:
Vol. 11, Issue 550, eaat0138
DOI: 10.1126/scisignal.aat0138

Help during hypoxia from HIR-1

Metazoans require a constant supply of oxygen, and inappropriate hypoxic adaptation is pathological—an example of which occurs in solid tumors. Using the model organism Caenorhabditis elegans, Vozdek et al. searched for pathways involved in coping with hypoxic environments and identified a receptor tyrosine kinase that they called HIR-1. Worms exposed to hypoxia had compromised cuticles, and this damage was recapitulated by loss of HIR-1. Moreover, worms lacking HIR-1 showed changes in the expression of genes involved in cuticle integrity and impaired recovery after severe hypoxia. If a human ortholog of HIR-1 is found, the authors speculate that it could be targeted to treat solid tumors.

View Full Text

Stay Connected to Science Signaling