Research ArticleBiochemistry
The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling
- Marco Biancucci1,*,
- View ORCID ProfileGeorge Minasov1,2,
- View ORCID ProfileAvik Banerjee3,
- View ORCID ProfileAlfa Herrera1,
- View ORCID ProfilePatrick J. Woida1,
- View ORCID ProfileMatthew B. Kieffer1,
- Lakshman Bindu4,
- Maria Abreu-Blanco4,
- View ORCID ProfileWayne F. Anderson2,5,
- Vadim Gaponenko6,
- Andrew G. Stephen4,
- View ORCID ProfileMatthew Holderfield4, and
- View ORCID ProfileKarla J. F. Satchell1,2,†
- 1Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
- 2Center for Structural Genomics of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
- 3Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
- 4National Cancer Institute-RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, MD 21702, USA.
- 5Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
- 6Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.
- ↵†Corresponding author. Email: k-satchell{at}northwestern.edu
↵* Present address: GSK Vaccines, Rockville, MD 20850, USA.
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Science Signaling 02 Oct 2018:
Vol. 11, Issue 550, eaat8335
DOI: 10.1126/scisignal.aat8335
Vol. 11, Issue 550, eaat8335
DOI: 10.1126/scisignal.aat8335
Marco Biancucci
1Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
George Minasov
1Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
2Center for Structural Genomics of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Avik Banerjee
3Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Alfa Herrera
1Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Patrick J. Woida
1Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Matthew B. Kieffer
1Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Lakshman Bindu
4National Cancer Institute-RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, MD 21702, USA.
Maria Abreu-Blanco
4National Cancer Institute-RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, MD 21702, USA.
Wayne F. Anderson
2Center for Structural Genomics of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
5Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Vadim Gaponenko
6Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.
Andrew G. Stephen
4National Cancer Institute-RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, MD 21702, USA.
Matthew Holderfield
4National Cancer Institute-RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, MD 21702, USA.
Karla J. F. Satchell
1Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
2Center for Structural Genomics of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
