Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations

Srgjan Civciristov; Andrew M. Ellisdon; Ryan Suderman; Cindy K. Pon; Bronwyn A. Evans; Oded Kleifeld; Steven J. Charlton; William S. Hlavacek; Meritxell Canals; Michelle L. Halls

doi:10.1126/scisignal.aan1188

Research ArticleGPCR SIGNALING

Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations

View ORCID ProfileSrgjan Civciristov¹,
View ORCID ProfileAndrew M. Ellisdon²,
View ORCID ProfileRyan Suderman³,
View ORCID ProfileCindy K. Pon¹,
Bronwyn A. Evans¹,
View ORCID ProfileOded Kleifeld²,⁴,
View ORCID ProfileSteven J. Charlton⁵,⁶,
View ORCID ProfileWilliam S. Hlavacek³,
View ORCID ProfileMeritxell Canals¹, and
View ORCID ProfileMichelle L. Halls ¹,*

¹Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
²Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
³Theoretical Biology and Biophysics Group, Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
⁴Faculty of Biology, Technion-Israel Institute of Technology, Technion City, Haifa 3200003, Israel.
⁵Cell Signalling Research Group, School of Life Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham NG7 2UH, UK.
⁶Excellerate Bioscience Ltd, MediCity, Nottingham NG90 6BH, UK.

↵*Corresponding author. Email: michelle.halls{at}monash.edu

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Science Signaling 09 Oct 2018:
Vol. 11, Issue 551, eaan1188
DOI: 10.1126/scisignal.aan1188

Srgjan Civciristov

1Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

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Andrew M. Ellisdon

2Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

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Ryan Suderman

3Theoretical Biology and Biophysics Group, Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

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Cindy K. Pon

1Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

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Bronwyn A. Evans

1Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

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Oded Kleifeld

2Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

4Faculty of Biology, Technion-Israel Institute of Technology, Technion City, Haifa 3200003, Israel.

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Steven J. Charlton

5Cell Signalling Research Group, School of Life Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham NG7 2UH, UK.

6Excellerate Bioscience Ltd, MediCity, Nottingham NG90 6BH, UK.

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William S. Hlavacek

3Theoretical Biology and Biophysics Group, Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

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Meritxell Canals

1Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

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Michelle L. Halls

1Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

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ORCID record for Michelle L. Halls
For correspondence: michelle.halls@monash.edu

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