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Research ArticleGPCR SIGNALING
Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations
- Srgjan Civciristov1,
- Andrew M. Ellisdon2,
- Ryan Suderman3,
- Cindy K. Pon1,
- Bronwyn A. Evans1,
- Oded Kleifeld2,4,
- Steven J. Charlton5,6,
- William S. Hlavacek3,
- Meritxell Canals1, and
- Michelle L. Halls1,*
- 1Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
- 2Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
- 3Theoretical Biology and Biophysics Group, Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
- 4Faculty of Biology, Technion-Israel Institute of Technology, Technion City, Haifa 3200003, Israel.
- 5Cell Signalling Research Group, School of Life Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham NG7 2UH, UK.
- 6Excellerate Bioscience Ltd, MediCity, Nottingham NG90 6BH, UK.
- ↵*Corresponding author. Email: michelle.halls{at}monash.edu
See allHide authors and affiliations
Science Signaling 09 Oct 2018:
Vol. 11, Issue 551, eaan1188
DOI: 10.1126/scisignal.aan1188
Vol. 11, Issue 551, eaan1188
DOI: 10.1126/scisignal.aan1188
Srgjan Civciristov
Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Andrew M. Ellisdon
Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
Ryan Suderman
Theoretical Biology and Biophysics Group, Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Cindy K. Pon
Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Bronwyn A. Evans
Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Oded Kleifeld
Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.Faculty of Biology, Technion-Israel Institute of Technology, Technion City, Haifa 3200003, Israel.
Steven J. Charlton
Cell Signalling Research Group, School of Life Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham NG7 2UH, UK.Excellerate Bioscience Ltd, MediCity, Nottingham NG90 6BH, UK.
William S. Hlavacek
Theoretical Biology and Biophysics Group, Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Meritxell Canals
Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Michelle L. Halls
Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
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